With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
3-Iodo-4-fluoro-methyl nicotinic acid (225 mg, 0.8 mmol) was dissolvedin N, N- dimethylformamide (5 mL), was added N, N- diisopropylethylamine (180mu, 1.09 mmol) and 2- (7-BTA) -Nu, Nu, Nu ‘, Nu’- tetramethyluroniumhexafluorophosphate (610 mg, 1.6 mmol), stirred for 5 min add 3 -trifluoromethyl-4- (4-methyl-piperazinyl small ylmethyl) aniline (198 mg, 0.72mmol), the reaction mixture was stirred at room temperature 26 h. Aftercompletion of the reaction system was added water, extracted with ethyl acetatetwice. The combined organic layer was purified by column chromatography togive 4-fluoro-3-iodo -N- [4- (4- methyl – piperazin-1-ylmethyl)-3-trifluoromethyl – phenyl] – nicotinamide (white solid, 420 mg)., 694499-26-8
As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.
Reference：
Patent; Shanghai Pharmaceuticals Holding Co.,Ltd .; WAN, HUIXIN; LI, CHUNLI; SHI, Chen; Liu, Haiyan; Li, Ping; XIA, Guangxin; HAN, Yanan; (52 pag.)CN103420977; (2016); B;,
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