438049-35-5, N-Boc-3-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1, 1′-carbonyldiimidazole (468 mg, 2.80 mmol) in anhydrous DMF (2 mL) were added triethylamine (0.59 mL, 4.20 mmol) and a solution of tert-butyl 3-ethylpiperazine-1-carboxylate (500 mg, 2.33 mmol) in anhydrous DMF (2 mL) dropwise. The mixture was stirred in a sealing tube at rt for 30 min, and then anhydrous methanol (12 mL) was added. The resulting mixture was further stirred at 60 for 24 h, and concentrated. The residue was diluted with saturated aqueous NaCl (30 mL) , and extracted with EtOAc (15 mL × 2) . The combined organic layers were dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 5/1 to give 4-tert-butyl 1-methyl 2-ethylpiperazine-1, 4-dicarboxylate as colorless liquid (260 mg, 40) .1H NMR (400 MHz, CDCl3) : delta ppm 3.88-3.97 (m, 4H) , 3.70 (s, 3H) , 2.76-3.02 (m, 3H) , 1.52-1.61 (m, 2H) , 1.45 (s, 9H) , 0.89 (t, J 7.4 Hz, 3H) and MS-ESI: m/z 173.1 [M+H-100] + ., 438049-35-5
438049-35-5 N-Boc-3-Ethylpiperazine 22219867, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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