With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
General procedure: To a stirring solution of compound 8 (200mg, 0.35mmol) in DCM (10mL) was added EDCI (91mg, 0.47mmol), HOBt (64mg, 0.47mmol) and the corresponding diamine derivatives (0.35mmol) with a drop of DIPEA. The reaction mixture was stirred for 12hat room temperature, then washed with diluted HCl and saturated brines. The organic layer were combined and dried over anhydrous Na2SO4, concentrated in vacuo, and then purified by flash chromatography to give product 9b-9h, 9k-9x, respectively.
934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference：
Article; Xu, Xiao-li; Yang, Ying-rui; Mo, Xiao-fei; Wei, Jin-lian; Zhang, Xiao-jin; You, Qi-dong; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 45 – 62;,
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