934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
934-98-5, To a solution of?(S)-7?(2.00 g, 7.0 mmol) in DCM (60 mL), DEPBT (2.01 g, 7.0 mmol) and DIPEA (2.44 mL, 14.0 mmol) were added and reaction mixture was stirred at room temperature for 5 min. 2-(4-Methyl-piperazin-1-yl)ethylamine?8b?(1.00 g, 7.0 mmol) was added to the reaction mixture and it was stirred at room temperature for 18 H. Mixture was quenched with H2O (60 mL) and organic layer was washed with brine (2×60 mL), dried over Na2SO4?filtered and evaporated. The residue was purified by flash column chromatography eluting with?DCM : MeOH (95 : 5) to afford 1.91 g of the titled compound?9b?as a white solid (66 percent):?mp 154-155 °C;??[alpha]D20+ 49.7 (c?1, MeOH);?deltaH?(400 MHz; CDCl3) 7.34-7.24 (10H, m), 6.27-6.25 (2H, m), 5.15-4.97 (3H, m), 3.24 (2H, q,?J?= 5.5 Hz), 2.40-2.29 (10H, m), 2.21 (3H, s);?13C NMR (300 MHz; CDCl3) 170.3, 139.4, 137.1, 129.9, 129.3, 129.2, 129.0, 128.9, 128.0, 67.8, 59.7, 56.5, 55.8, 53.4, 46.9, 37.0;?HR-MS [M + H]+?observed = 411.2410, calculated = 411.2391.
As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference：
Article; Hanessian, Stephen; Babonneau, Vincent; Boyer, Nicolas; Mannoury La Cour, Clotilde; Millan, Mark J.; De Nanteuil, Guillaume; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 510 – 514;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics