With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
mCPBA (<77% pure) (61.1 mg, assumed 0.273 mmol) in DCM (0.5 mL) was added to a stirred solution of 8-bromo-6- (2 , 6 -dichlorophenyl ) -2- (methylthio) pyrido [4 , 3 -d] pyrimidin-5 (6H) -one (98.4 mg, 0.236 mmol) in toluene (4.0 mL) at RT under nitrogen. After 20 min, DIPEA (0.124 mL, 0.708 mmol) and tert-butyl 4- (4- aminophenyl) piperazine-l-carboxylate (72.0 mg, 0.260 mmol) [commercially available] were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture was allowed to cool to RT, and was loaded onto a KP-NH column and purified by flash chromatography (0- 50%, EtOAc in cyclohexane) to give the title compound (125 mg, 82%) as a brown solid. LCMS (Method A) : RT = 1.67 min, m/z = 647 [M+H]+., 170911-92-9
As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.
Reference：
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin Roderick; ROUNTREE, James Samuel Shane; BURKAMP, Frank; WILKINSON, Andrew John; WO2014/167347; (2014); A1;,
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