163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step B: (R)-tert-Butyl 4-(cis-4-(2-chloro-5-nitropyridin-4- ylamino)cyclohexanecarbonyl)-3-methylpiperazine-l-carboxylate. A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)cyclohexanecarboxylic acid hydrochloride (0.5 g, 1.487 mmol) in thionyl chloride (10.86 mL, 149 mmol) was heated at 70C for 1.5 hours. The mixture was concentrated under reduced pressure and dried under high vacuum for 1 hour. The resulting solid was suspended in THF (14.87 mL) and cooled to 0C under nitrogen atmosphere. To this mixture was added (R)-tert-butyl 3- methylpiperazine-l-carboxylate (0.357 g, 1.785 mmol) as a solution in THF (5 mL). The ice bath was removed, and the reaction mixture was stirred overnight at RT. The resulting mixture was diluted with DCM (lOOmL) and washed with saturated aqueous NaHC03 solution (30 mL) and then with saturated aqueous ammonium chloride solution (2x). The organic phase was collected, dried over sodium sulfate, and concentrated under reduced pressure to afford (R)-tert-butyl 4-(cis-4-(2-chloro-5-nitropyridin-4- ylamino)cyclohexanecarbonyl)-3-methylpiperazine-l-carboxylate as a light yellow solid (0.55 g, 77 % yield). MS = 482.2 [M+H]. Calc’d for C22H32C1N505: 481.2.
163765-44-4, As the paragraph descriping shows that 163765-44-4 is playing an increasingly important role.
Reference：
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Piperazine – Wikipedia
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