138775-02-7, (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(2/?)-4-[(benzyloxy)carbonyl]-1 -[(ferf-butoxy)carbonyl]piperazine-2-carboxylic acid (4.00 g, 1 1.0 mmol), DIPEA (5.1 ml_, 27.4 mmol), HATU (5.01 g, 13.2 mmol) and N,0- dimethylhydroxylamine hydrochloride (1.29 g, 13.2 mmol) in DMA (40 ml.) are stirred at rt over the weekend. The reaction mixture is diluted with EtOAc, and washed with water and brine. The organic layer is dried over MgS04, filtered, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (EtOAc/heptane) to afford the title compound. (0734) Yield: 4.44 g (99%) ESI-MS: m/z = 408 (M+H)+, 138775-02-7
The synthetic route of 138775-02-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BRUNETTE, Steven; CUI, Jianwen; LOWE, Michael D.; SARKO, Christopher Ronald; SURPRENANT, Simon; TURNER, Michael Robert; WU, Xinyuan; SMITH KEENAN, Lana Louise; BOUYSSOU, Thierry; (183 pag.)WO2019/158572; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics