With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 3 (100 mg, 0.23 mmol) in acetonitrile (CH3CN, 30 mL) was added thecorresponding arylpiperazine (1.2 equiv.) and potassium carbonate (6.0 equiv.). The reaction mixturewas stirred at reflux for 16 h. After cooling to ambient temperature, the reaction mixture was filteredthrough a Buchner funnel. After filtration, the filtrate was concentrated in vacuo and the residue waspuried by silica gel column chromatography using ethyl acetate/petroleum ether (1/4,v/v) as eluentto afford the corresponding products (4-21).
115761-79-0, 115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Chen, Hong; Xu, Bing-Bing; Sun, Tao; Zhou, Zhan; Ya, Hui-Yuan; Yuan, Mu; Molecules; vol. 22; 11; (2017);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics