20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
22.8) 5-Chloro-thiophene-2-carboxylic acid [(S)-3-(4-cyclopropyl-piperazin-1-yl)-2-(2- methyl-3-pyridin-3-yl-benzenesulfonylamino)-3-oxo-propyl]-amide dihydrochloride: Intermediate 78 (202 mg, 0.42 mmol) was dissolved in 10 ml DCM and N-cyclopropyl piperazine (105 mg, 0.84 mmol) was added followed by DIPEA (0.29 ml, 1.68 mmol) and TBTU (202 mg, 0.63 mmol). After stirring for 1 h at RT the solution was evaporated to dryness and purified by silica gel chromatography (Elution with DCM/methanol from 0 to 10% of methanol). The solid obtained after evaporation of the solvents was dissolved in DCM, HCI 2M in Et2O (5 ml) was added and the solvents were evaporated. Yield: 163 mg, 59 %. MS (ES+): m/e = 588.
20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANOFI-AVENTIS; WO2009/103440; (2009); A1;,
Piperazine – Wikipedia
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