With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
[14031 Step 1: Synthesis of (E?)-methyl3-(4-(((3R.55?)-3 .5-dimethylpiperazin- 1 -yl?)methyl?)phenyl?)acrylate [14041 (2S ,6R)-2,6-dimethylpiperazine (0.500 g, 4.379 mmol), (E)-methyl3-(4-(bromomethyl)phenyl)acrylate (formula 8-4, 1.173 g, 4.598 mmol) and Cs2CO3 (2.140 g, 6.568 mmol) were dissolved in acetonitrile (10 mL) at room temperature, and the reaction solution was stuffed at the same temperature for 5 hours. Then, the reaction mixture was filtered through a glass filter to remove solids, and the filtrate was con-centrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide, 12 g cartridge; methanol/methylene chloride = from 0 percent to 15 percent) and concentrated to afford the desired compound (1.090 g, 86.3 percent) as an orange solid., 21655-48-1
21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
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