With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
Example 53: -r2-(4-methv.-piDerazin-1 -vn-ethvi1-3-r3-(5-thioDhen-3-vi-Dvrimidin-2-viamino)-Dhenvt1-urea; To a stirring solution of W (100 mg, 0.23 mmol) in CH2CI2 (20 mL) was added J (33 mg, 0.23 mmol) followed by triethylamine (32 muL, 0.23 mmol). The solution was stirred at room temperature for 12 hours where the reaction was diluted with CH2Cl2 (50 mL) and washed with 2N NaOH (2 x 50 mL), water (2 x 50 mL) and brine (2 x 50 mL). The organics were dried over Na2S04 and concentrated in vacuo. The residue was purified using column chromatography (silica gel, 5percent MeOH in CH2CI2). The fractions containing product were evaporated to dryness under vacuum to yield compound 53 in 45percent yield as a white solid. (at)H NMR (300 MHz, CD30D) No. 2.27 (s, 3H), 2.33-2.55 (m, 7.01-7.02 (m, 1H), 7.04-7.05 (m, 2H), 7.43 (d, 1 H), 7.45 (d, 1 H), 7.64 (d, 1 H), 7.86 (d, 1 H), 8.72 (s, 2H). MS m/z 438 [M++1].
As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference：
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
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