With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54699-92-2,4-Methyl-1-piperazineacetic acid,as a common compound, the synthetic route is as follows.
54699-92-2, 36) 2-(4-methylpiperazin-1-yl)acetyl chloride [Show Image] Oxalil chloride (0.3 ml, 3.47 mmol) was added dropwise to a stirred solution of (4-Methyl-piperazin-1-yl)-acetic acid (500 mg, 3.16 mmol) 15 ml of dry THF and placed under inert atmosphere. Two drops of dimethylformammide were added. The reaction mixture was refluxed for 1 h, and the solvent removed under reduced pressure giving 440 mg (80%) (4-Methyl-piperazin-1-yl)-acetyl chloride as a yellow solid. 1H-NMR (DMSO, 400 MHz), delta (ppm): 3.20 (2H, s), 2.78 (8H, m), 2.60 (3H, s).
54699-92-2 4-Methyl-1-piperazineacetic acid 2762732, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Universita Degli Studi Di Milano – Bicocca; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD – LYON 1; EP2107054; (2009); A1;,
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