With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step C: tert-butyl(3S)-3-(hydroxymethyl)-4-[2-hydroxy-2-( 1-oxo- 1 ,3-dihydro-2-benzofuran-5-yl)ethyll piperazine- 1 -carboxylate: 5- (Oxiran-2-yl)-2-benzofuran- 1 (3H)-one (1.5 g, 8.5 mmol)and commercially available (S)-4-N-BOC-2-hydroxymethyl piperazine (2.394 g, 11.07 mmol)were combined in ethanol (10 mL) in a microwave tube. The mixture was degas sed then heated for 60 mm at 150 C. LC-MS showed the product peak. The reaction was worked up by adding ethyl acetate and washing once with brine. The organic layer was separated, dried, andconcentrated to dryness. The crude product was purified by MPLC using an 80g Redi-sep column and eluted with 50%-i 00% EtOAc hexane yielding the title compound.
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
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