With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.502649-32-3,1-Boc-3-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
502649-32-3, A mixture of 10- hydroxy-10-((6-oxo-4-phenylpyrimidin-1 (6/-/)-yl)methyl)-7-azaspiro[4.5]decane-7-carbonyl chloride (10 mg, 0.0249 mmol), tert- butyl 3-isopropylpiperazine-1-carboxylate (8.5 mg, 0.0373 mmol) and DIPEA (13 mI_, 0.0746 mmol) in DCM (0.5 mL) was stirred at rt for 2 h 30 min before tert- butyl 3-isopropylpiperazine-1-carboxylate (8.5 mg, 0.0373 mmol) and DIPEA (13 pL, 0.0746 mmol) were added. The reaction was stirred for further 18 h 45 min before DMF (0.5 mL) was added and the reaction stirred for a further 6 days. The reaction mixture was diluted with saturated NaHC03(aq) (15 mL) and the resulting mixture was extracted with DCM (3 x 10 mL) using a phase separator. The combined organic phases were concentrated under reduced pressure and the residue was purified by flash (1504) chromatography (0-100% EtOAc in cyclohexane) to give the title compound (7.7 mg, 52%) as colourless glass. LCMS (Method A): RT = 1.70 min, m/z = 594 [M+H]+.
502649-32-3 1-Boc-3-Isopropylpiperazine 44558596, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
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