314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A vial was charged with 5-amino-3,6-dichloro-l,2,4-triazine (253.3 mg, 1.535 mmol), diisopropylethylamine (2.0 mL, 1 1.48 mmol), (S)-tert-butyl 2-(3- (hydroxymethyl)piperazin-l-yl)acetate (410.9 mg, 1.731 mmol) in dioxane (2 mL). The mixture was heated at 120 C for 5 h using microwave. The mixture was concentrated to remove all of solvent. The residue was dissolved in dichloromethane, washed with aqueous sodium bicarbonate solution. The organic solution was separated. The aqueous solution was mixed with brine, extracted with dichloromethane (2 x 35 mL). The combined organic solution was dried over anhydrous sodium sulfate, concentrated to afford a residue. The residue was dissolved into small amount of dichloromethane, filtered. The solid was collected the first batch of product. The solution was purified with flash column chromatography on silica using 1-10% methanol in dichloromethane to afford another batch of product. The product was slight yellow solid (343 mg) and the yield was 65%. NMR (500 MHz, Chloroform-d) delta 5.26 (br, 2H), 4.76 (s, lH), 4.43 (d, J = 13.3 Hz, lH), 4.23 – 3.92 (s, 2H), 3.65 (m, 2H), 3.16 – 2.90 (s, 4H), 1.47 (s, 9H). MS for Ci3H21ClN603: 345.0 (MH+)., 314741-40-7
As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference：
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
Piperazine – Wikipedia
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