With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
C the steps of the compound (50 mg, 0.16 mmol), 4 – ((4-methyl-piperazinyl) methyl) aniline (0.176 mmol), 1 – (3-dimethylamino-propyl) – 3-ethyl carbodiimide hydrochloride (0.24 mmol), 1-hydroxybenzotriazole and triazazole (0.24 mmol) and triethylamine (50 microliters) dissolved in dry N, N-dimethyl formamide in (3 ml), stir at room temperature overnight. Water 20 ml, ethyl acetate (10 ml, 5 times) extraction, extraction fluid after full and salt water washing, drying by anhydrous sodium sulfate, column chromatography (dichloromethane/methanol =1/10) separated to obtain title compound 20 mg per litre. MS:m/z, 499.2(M+H)., 70261-82-4
As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.
Reference：
Patent; CHIA TAI TIANQING PHARMACEUTICALGROUP CO LTD; Beijing Centaurus Biopharma Technology?Co.,?Ltd.; XIAO, DENGMING; LIANG, ZHI; HU, YUANDONG; HU, QUAN; ZHANG, QINGHUI; HAN, YONGXIN; WANG, HUAN; PENG, YONG; KONG, FANSHENG; LUO, HONG; (60 pag.)CN103130792; (2016); B;,
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