With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.
5747-48-8, A solution of PDBTZ (1 mmol) and alpha-acetoxyethyl 4-nitrophenyl carbonate (1 mmol) in hexamethylphosphoramide (1.3 rnL) is stirred at ambient temperature until complete by thin layer chromatography. The mixture is diluted with water (35 mL) and extracted with diethyl ether. The extract is washed (aqueous sodium hydroxide, water), dried (sodium sulfate), evaporated, and purified by flash chromatography to provide the title compound.
The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; WO2008/79839; (2008); A1;,
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