With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Synthesis of 6-Fluoro-7-{4-[2-hydroxy~3~(2-methyl-5-nitro~imidazol-l- yl) -propyl J-piperazin-1 -yl}-l -methyl-4-oxo-4H-2-thia-8b-aza- cyclobuta[a]naphthalene-3-carboxylic acid (2): To a stirred solution of 6-Fluoro- 1 -methyl -4-oxo-7-piperazin- 1 -yl-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3- carboxylic acid, (III) (0.2g, 0.57mmol) in acetone (15ml) was added potassium carbonate (0.1 Ig, 0.19mmol) dissolved in water (5ml), followed by addition of epoxy ornidazole,(II)(0.15g, O.S2mmol). The reaction mixture was heated at 50 C for 20 hr. After completion, the reaction mixture was evaporated and extracted twice with dichloromethane. The combined organic layer was dried over sodium sulphate and evaporated to obtain the crude mass. The crude mass was purified by column chromatography by eluting with 10-12% methanol/dichloromethane mixture to obtain the pure compound (2), i.e., Compound 91 from Table 1, with 25-30% isolated yield. 1H-NMR (400 MHz, DMSO) 5ppm: 2.12 (3H, d, J – 6.4 Hz, CH3), 2.46 (3H, s, CH3), 2.58-2.60 (2H, t, J = 5.6 Hz CH2N ), 2.66 (4H, m, 2 x CH2), 3.2 (4H, m, 2 x CH2), 3.9-4.1 (2H, m, 2 x CH2N), 4.63 (1H, d, J= 14 Hz, CHOH), 5.15 (1H, d, J = 5.2 Hz -OH), 6.39 (1 H, d, J = 6.4 Hz, CHSN) 6.93 (1H, d, J = 7.2 Hz , Ar-H), 7.79 (1H, d, J = 14 Hz, Ar-H), 8.04 (1H, s, Ar-H). ESI-MS (m z): 532.95(M+H).
112984-60-8, The synthetic route of 112984-60-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; CHAWRAI, Suresh Rameshlal; GHOSH, Shamik; GHOSH, Sumana; JAIN, Nilu; SADHASIVAM, Suresh; BUCHTA, Richard; BHATTACHARYYA, Anamika; WO2015/114666; (2015); A2;,
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