With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.848482-93-9,(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,848482-93-9
To a stirred suspension of (S)-4-/V-Boc-piperazine-2-carboxylic acid (502 mg, 2.18 mmol) in water (2.5 mL) was added NaHC03(366.2 mg, 4.36 mmol), and the resulting suspension was stirred at ambient temperature for 30 minutes. A solution of benzyl chloroformate (744 mg, 4.36 mmol) in dioxane (4 mL) was then added and the reaction mixture was stirred at ambient temperature overnight. The reaction mixture was then diluted with water (5 mL) and extracted with EtOAc (2 15 mL). The combined organic layer was washed brine, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The remaining residue was then dissolved in DMF (7 mL) and K2CO3 (904 mg, 6.54 mmol) was added. After stirring for 5 minutes, CH3I (928 mg, 6.54 mmol) was added slowly and the resulting mixture was stirred at ambient temperature for 2 h. The reaction was quenched with H2O and extracted with EtOAc (2X 15 mL).The combined organic layer was washed with brine, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to leave brown oil as the product (800 mg, quant.).1H NMR (400 MHz, CDCI3) delta 7.42 – 7.31 (m, 5H), 5.22 – 5.09 (m, 2H), 4.84 – 4.63 (m, 1 H), 4.63 – 4.47 (m, 1 H), 4.11 – 3.81 (m, 2H), 3.72 (d, J = 22.6 Hz, 3H), 3.32 (s, H), 3.08 (d, J = 13.5 Hz, H), .44 (s, 9H). Mass calculated for (Ci9H26N206+H)+379.2, found 379.1.
The synthetic route of 848482-93-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SIMON FRASER UNIVERSITY; CENTRE FOR DRUG RESEARCH AND DEVELOPMENT; YOUNG, Robert Norman; KUMAR, Nag Sharwan; MANDEL, Alexander Laurence; HSIEH, Tom Han Hsiao; TAN, Jason Samuel; SHIDMOOSSAVEE, Fahimeh S.; JAQUITH, James Brian; DULLAGHAN, Edith Mary; (467 pag.)WO2017/75694; (2017); A1;,
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