129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,129799-15-1
To a solution of 1-tert-butyl 2-methyl piperazine-1, 2-dicarboxylate (0.2g, 0.82 mmol) and triethylamine (1.2 mL, 8.2 mmol) in anhydrous THF (5 mL) atrt was added trimethylsilyl isocyanate (1.1 mL, 8.2 mmol) dropwise. The mixturewas stirred at rt for 8 h and quenched with ice-water (10 mL) , and then THFwas removed. The aqueous layer was extracted with EtOAc (10 mL × 3) . The combined organiclayers were dried over anhydrous Na2SO4 and concentratedto give 1-tert-butyl 2-methyl 4-carbamoylpiperazine-1, 2-dicarboxylate asa white solid (0.3 g, 90) . 1H NMR (400 MHz, CDCl3): delta ppm 4.24 (br.s, 2H) , 4.30 (d, J 13.3 Hz, 1H) , 3.98-4.14 (m, 1H) ,3.83-3.94 (m, 1H) , 3.78 (s, 3H) , 3.18-3.28 (m, 1H) , 3.03-3.12 (m, 1H) ,2.79-2.96 (m, 1H) , 1.50 (d, J 16.7 Hz, 9H) and MS-ESI: m/z 232.25 [M-55] +.
The synthetic route of 129799-15-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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