78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78818-15-2
EXAMPLE A; Preparation of Compound A of Formula 1 Process for the Preparation of Compound A-In-2:[00118] This compound was prepared by the method described by Bryant, HJ. et al, in WO 01/44250.[00119] To a stirred and cold (ice-bath cooling) suspension of benzyl 3- oxopiperazine-1-carboxylate (A-In-I) (1.00 g) and K2CO3 (11.8 g) in CH2Cl2 (40 mL) was added under N2 trimethyloxonium tetrafluoroborate (2.20 g, from Aldrich) in one portion. The cooling bath was removed and the mixture was stirred at room temperature under N2 for 19 h. This mixture was poured into water (40 mL) under ice-cooling and the organic phase was collected. The aqueous phase was extracted with CH2Cl2. The combined CH2Cl2 phases were washed with water (20 mL), then with brine, dried (Na2SO4) and concentrated. The crude residual oil was purified by silica gel column chromatography (5% MeOH/CH2Cl2) to give the title compound A- In-2 as colorless oil.
The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/158394; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics