78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
78818-15-2, Step C Preparation (+-)-4-Benzyloxycarbonyl-1-[1-(3-(benzyloxy)phenyl)-3-buten-1-yl]-2-piperazinone Sodium hydride (1.20 g, 30.0 mmol, 60% mineral oil dispersion) was triturated with hexane. The flask was charged with 15 mL of dimethylformamide and cooled to 0 C. 4-Benzyloxycarbonyl-2-piperazinone was added (4.55 g, 19.4 mmol), and the reaction was stirred for 15 minutes at 0 C. A solution of the product from Step B (4.83 g, 14.5 mmol) in 15 mL of dimethylformamide was added slowly, and the reaction was allowed to warm to room temperature. After 3 days, the solution was concentrated in vacuo, and partitioned between EtOAc and saturated NaHCO3 solution. The aqueous phase was extracted with EtOAc, and the combined organics were washed with saturated NaHCO3 soln and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The resulting product was purified by silica gel chromatography (10% EtOAc/hexane, then 5% MeOH/CH2Cl2) to provide the titled product as a yellow oil.
The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Merck & Co., Inc.; US6562823; (2003); B1;,
Piperazine – Wikipedia
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