With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
50606-32-1, 3.2. 4-((S)-2-tert-Butoxycarbonylamino-4-ethoxycarbonyl-butyryl)-piperazine-l-carboxylic acid butyl ester To a solution of intermediate 3.1 (8.75 g) in CH2Cl2 (50 mL) / THF (20 mL) was added HOBT (4.94 g). After 15 min, was added EDCI-HCl (6.70 g) and the reaction mixture further stirred for 20 min. Piperazine-1-carboxylic acid butyl ester (6.22 g, prepared as described in WO2008044217) was added and the reaction mixture stirred until reaction completion at RT. The mixture was poured onto an ice-cold aq. citric acid solution (5%), and the precipitate filtered off. The filtrate was extracted with Et2O (3×200 mL), the org. phase washed with aq. citric acid (5%, 4×50 niL), sat. aq. Na2CO3 solution and brine. The combined org. layers were dried over MgSO4 and evaporated to give 13.O g of the desired product. LC-MS: tR = 1.01 min; [M+H]+: 444.49.
50606-32-1 Butyl piperazine-1-carboxylate 21963126, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/122504; (2010); A1;,
Piperazine – Wikipedia
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