132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of tert-butyl 4-(3-hydroxypropyl)piperazine-l-carboxylate (7.0 g, 28.64 mmol) in THF (50 mL), was added triethylamine (8 mL, 57.29 mmol) at room temeperature. After 5 min, benzoyl chloride (3.66 mL, 31.51 mmol) was added dropwise at 0 C under inert atmoshphere. After addition, the resultant reaction mixture was stirred at room temperature for 1 h. After completion of reaction (monitored by TLC), the reaction was quenched with water (100 mL) and extracted with ethyl acetate (3 X 250 mL). The combined organic layer was dried over anhydrous sodium sulphate and concentrated – – under reduced pressure to afford 43 (7.8 g) as a off-white solid. *H NMR (400 MHz, CDC13): delta 8.06 – 8.00 (m, 2H), 7.59 – 7.52 (m, 1H), 7.48 – 7.40 (m, 2H), 4.38 (tj = 6.6 Hz, 2H), 3.50 – 3.39 (m, 4H), 2.53 (t, / = 7.3 Hz, 2H), 2.43 (br t, / = 4.9 Hz, 4H), 1.98 (quin, / = 6.8 Hz, 2H), 1.46 (s, 9H); LCMS (M+H) = m/z 349.7 [M+H+]; purity~83%., 132710-90-8
132710-90-8 1-Boc-4-(3-hydroxypropyl)piperazine 16217800, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; TOPADUR PHARMA AG; NAEF, Reto; TENOR, Hermann; (135 pag.)WO2017/85056; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics