With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
To a solution of CBz-piperazine (0.84 ml_, 4.36 mmol) in CH2CI2 (22 ml_) was added EDC (0.918 g, 4.79 mmol), HOBt (0.645 g, 4.77 mmol), Boc-D-Pip- OH (1.03 g, 4.50 mmol), and triethylamine (0.74 mL, 5.31 mmol) and the reaction stirred at room temperature for 5 days. The reaction was diluted with CH2CI2 and washed with sat. NaHCO3, 1 N HCI, sat. NaHCO3, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated to produce 1.87 g (-99percent) of crude title compound: LCMS (m/z): 432.2 (M + H)., 31166-44-6
The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
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