129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1,3-dibromobenzene (1.10 g, 4.67 mmol), (cis)-tert-butyl 3,5- dimethylpiperazine- 1 -carboxylate (0.5 g, 2.33 mmol) and 2-dicyclohexylphosphino-2?,6?- dimethoxy- 1,1 ?-biphenyl (47.9 mg, 0.117 mmol) in THF (15 mL) in a pressure reactionvial was purged with nitrogen. Tris(dibenzylideneacetone)dipalladium(0) (42.7 mg,0.047 mmol) was added, followed by lithium bis(trimethylsilyl)amide (7.0 mL, 7.0 mmol,1 N in THF). The mixture was purged with nitrogen for several mm and then capped andheated at 70 C for 2.5 h. The reaction mixture was cooled and quenched with aq.NaHCO3, then diluted with 75 mL of EtOAc, washed with H20, brine, dried andconcentrated. The residue was purified on silica gel, with a linear gradient of 0-100%EtOAc/hexanes to give (cis)-tert-butyl 4-(3 -bromophenyl)-3 ,5 -dimethylpiperazine- 1- carboxylate (0.505 g) as an oil. LCMS, M+H = 369.2/37 1.2 Method G. Rt. 3.55 mm.
129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; BATT, Douglas G.; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; LIU, Qingjie; MARCOUX, David; NEELS, James; POSS, Michael A.; QIN, Lan-ying; RUAN, Zheming; SHI, Qing; SRIVASTAVA, Anurag S.; TINO, Joseph A.; WATTERSON, Scott Hunter; (532 pag.)WO2016/64957; (2016); A1;,
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