With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
A mixture of the 2- (5-amino-2- (furan-2-yl) -8H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-8-yl) -4-methylpentanoic acid (35.5 mg, 0.1 mmol) , 1- (2, 4-difluorophenyl) piperazine (19.8 mg, 0.1 mmol) , HATU (46 mg, 0.12 mmol) and DIPEA (25.8 mg, 0.2 mmol) in DMF (3 mL) was stirred overnight. The reaction mixture was poured into H2O (15 mL) and extracted with EtOAc (20 mL x 3) . The combined organic layers were washed with brine, dried over Na2SO4, concentrated and purified by column chromatography (petroleum ether/EtOAc = 10: 1 3: 1) to give the target compound (20 mg, 37.3%) .1H NMR (400 MHz, DMSO-d6) delta 8.78 (s, 1H) , 7.94 (s, 1H) , 7.65 (s, 2H) , 7.25 -7.17 (m, 2H) , 7.03 (m, 2H) , 6.74 (dd, J = 3.2, 1.6 Hz, 1H) , 5.69 (m, 1H) , 3.76 (s, 2H) , 3.64 (m, 2H) , 3.05-2.93 (m, 2H) , 2.91 -2.79 (m, 2H) , 2.28 -2.17 (m, 1H) , 1.89 -1.78 (m, 1H) , 1.35 (m, 1H) , 0.97 (d, J = 6.4 Hz, 3H) , 0.88 (d, J = 6.4 Hz, 3H) ppm. MS: M/e 536 (M+1)+., 115761-79-0
The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Piperazine – Wikipedia
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