With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
120737-59-9, TO a solution of 2-cyclohexylamino-4, 6-dichloro-1, 3,5-triazine (example 7, step A) (706mg) in DCM (5mL) at 0°C was added 3-METHYL-PIPERAZINE-1-CARBOXYLIC acid tert- butyl ester (579mg) and DIPEA (502PL). The mixture was allowed to warm to room temperature and stirred for 1 hour. The mixture was extracted with DCM (20mL) and washed with HCl (20ml), 1M), solvent was then removed under reduced pressure to yield 2-CHLORO-4-CYCLOHEXYLAMINO-6- (4-TERT-BUTOXYCARBONYL-2-METHYLPIPERAZIN-1-YL)- 1,3, 5-triazine (840mg) as a white powder. MS M/Z 411. 0 (M+1).
The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AKZO NOBEL N.V.; WO2005/11703; (2005); A1;,
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