With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.
A mixture of EXAMPLE 1H (1.55 g), EXAMPLE IE (2.42 g), and HK2P04 (1.42 g) in dimethylsulfoxide (20 mL) at 135 C was stirred for 24 hours. The reaction was cooled, diluted with ether (400 mL), and washed three times with 1M aqueous NaOH, and brine, and concentrated. The residue was purified by flash chromatography, eluting with 10-50% ethyl acetate in hexanes to provide the title compound., 1228780-72-0
As the paragraph descriping shows that 1228780-72-0 is playing an increasingly important role.
Reference：
Patent; ABBOTT LABORATORIES; TAO, Zhi-Fu; WANG, Xilu; SOUERS, Andrew J.; CATRON, Nathaniel D.; SULLIVAN, Gerard; WO2011/150016; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics