17766-28-8, 1-Cyclohexylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 2Preparation of 4-((3-(4-cvclohexylpiperazin- 1 -yl)-6-oxo-6H-anthra[ I 9-cdIisoxazoI-5- yl)arnino)benzoic acid, About 70g of 4-((3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5- yl)amino)benzoic acid was dissolved in 95OmL of DMSO. About 5OmL of TEA and 50g of 1- cyciohexyl piperazine were added to the reaction. Temperature was raised to 60-70C. After 2-3hours, slowly added 500mL of MTBE and MeOH (10:1) solution and adjusted the temperature to40-50C. The solid was centrifuged and washed by IOOrnL of MTBE and MeOH solution and followed by iOOrnL of MeOH. Solid was dried under reduced pressure at 25-30C for 12-24 hours to obtain the 4-ft3-(4-cyclohexyipiperazin-i-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5- yl)amino)henzoic acid at about 98% purity and about 91% yield.
17766-28-8 1-Cyclohexylpiperazine 87298, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; VM PHARMA LLC; WU, Jay Jie-Qiang; WANG, Ling; (83 pag.)WO2016/43975; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics