SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.
Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.
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