Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays.Recommanded Product: 66-71-7.
Two new pentacoordinated copper(II) hydrazone coordination compounds with 2,2′-bipyridine (i) or 1,10-phenanthroline (ii) as coligands were synthesized and characterized in the solid state and in solution by spectroscopic methods (FTIR, Raman, UV-visible, EPR). Single crystal x-ray studies show that they have closely related mol. structures with the copper center in a distorted square pyramidal O2N3 environment. The N-acylhydrazone, [4-hydroxy-NN-(E)2-hydroxy-3-methoxybenzylidene]benzohydrazide, H2L, coordinates tridentate through its ONO donor atoms as monoanion (HL-) in the cationic complex (i), [Cu(HL)(bipy)](NO3). During the period that takes the synthesis reaction of compound (ii), [Cu(L)(o-phen)] to complete, keto-amine to enol-imine tautomerization of H2L occurs and the hydrazone coordinates tridentate as dianionic ligand (L2-). The fivefold coordination sphere of the complexes is completed with the nitrogen atoms of the resp. coligands. Cytotoxicity studies against bone (MG-63, IC50(I) = 5.6 ± 1.0, IC50(II) = 3.5 ± 0.3), breast (MCF7, IC50(I) = 10.8 ± 1.9, IC50(II) = 4.0 ± 1.3), (MDA-MB-231, IC50(I) = 11.4 ± 0.6, IC50(II) = 5.3 ± 0.2) and lung cancer cells (A549, IC50(I) = 7.7 ± 0.7, IC50(II) = 7.0 ± 0.4) reveals increased effectiveness of both complexes compared with the free ligand, the copper nitrate salt and the reference metallodrug cisplatin (CDDP).
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics