With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
A solution of the product of EXAMPLE 18A (70 mg, 0.21 mmol), tert-butyl 4-(4- amino-2-fiuorophenyl)piperazine- l -carboxy late (61 mg, 0.21 mmol) and catalytic p- toluenesulfonic acid (5 mg) in n-butanol (3 mL) was heated at 100C for 18 hours. After cooling to ambient temperature, the mixture was poured into saturated aqueous sodium bicarbonate (50 mL). The resulting solution was extracted with ethyl acetate (3 x 30 mL), and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography using 20: 1 dichloromethane/methanol to afford the crude title compound which was used in the next step without further purification. MS: 598 (M+H4).
154590-35-9, As the paragraph descriping shows that 154590-35-9 is playing an increasingly important role.
Reference£º
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas, Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97479; (2012); A1;,
Piperazine – Wikipedia
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