Tryniszewski, Michal; Basiak, Dariusz; Barbasiewicz, Michal published the artcile< Olefination with Sulfonyl Halides and Esters: Synthesis of Unsaturated Sulfonyl Fluorides>, Name: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is unsaturated sulfonyl fluoride preparation; sulfonyl halide ester arylaldehyde olefination.
Methanedisulfonyl fluoride, CH2(SO2F)2, transforms aromatic aldehydes into β-arylethenesulfonyl fluorides, useful substrates for the SuFEx “”click””-type transformations. The reaction mimics mechanism of the Horner-Wadsworth-Emmons olefination, which runs via addition of the carbanion, followed by cyclization-fragmentation of the four-membered ring intermediate. In the absence of base, electron-rich aldehydes follow an alternative pathway of the Knoevenagel condensation to provide unsaturated 1,1-disulfonyl fluorides. Authors demonstrate also trapping of elusive ethene-1,1-disulfonyl fluoride, CH2=C(SO2F)2, with 4-(dimethylamino)pyridine (DMAP) that forms zwitterionic adduct, characterized with X-ray studies.
Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Name: 1-Boc-4-(4-Formylphenyl)piperazine.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics