Dong, Weizhe; Badir, Shorouk O.; Zhang, Xuange; Molander, Gary A. published the artcile< Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis>, Product Details of C13H19BrN4O2, the main research area is trimethylsilylmethanamine aryl bromide nickel catalyst regioselective aminoalkylation; aryl methanamine preparation.
A general aminoalkylation of aryl halides were developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals were generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides were also amenable.
Organic Letters published new progress about Alkylation, chemoselective. 374930-88-8 belongs to class piperazines, and the molecular formula is C13H19BrN4O2, Product Details of C13H19BrN4O2.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics