On December 31, 1995, Li, Lu; Tong, Zengshou; Gan, Guizhi published an article.Product Details of 67914-60-7 The title of the article was Synthesis of ketoconazole derivatives. And the article contained the following:
Title compounds I [R = Ac, P(O)(OEt)2, P(O)(OCHMe2)2] were prepared E.g., reaction of I (R = H) with di-Et phosphite, Et3N, and CCl4 in N,N-dimethylacetamide, CH2Cl2, and benzene gave 86% I [R = P(O)(OEt)2]. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Product Details of 67914-60-7
The Article related to ketoconazole derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 67914-60-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics