On August 31, 1977, Saikawa, Isamu; Takano, Shuntaro; Yoshida, Chosaku; Takashima, Okuta; Momonoi, Kaishu; Yasuda, Takashi; Kasuya, Kyoko published an article.Name: 4-Ethyl-piperazine-1-carbonyl chloride The title of the article was Studies on 尾-lactam antibiotics for medicinal purposes. I. Synthesis of D(-)-伪-[(monooxo)-1-piperazinecarboxamido]benzylpenicillins and structure-antibacterial activity. And the article contained the following:
D-(-)-I (R1 = Me, Et, PhCH2, Ac, MeSO2, Ph), D-(-)-II (R1 = C1-4 alkyl, PhCH2, Ac, EtCO, PrCO, BuCO, ClCH2CO, MeSO2), and D-(-)-III (R1 = H, C1-4 alkyl, PhCH2, allyl) were prepared by N-acylation of aminobenzylpenicillin (IV). In vitro bactericidal activity of I – III against S. aureus, E. coli, P. aeruginosa, P. vulgaris, and K. pneumoniae decreased in the order of II > I > III. The bactericidal activity of these compounds against P. aeruginosa and K. pneumoniae was stronger than that of IV or carbenicillin. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Name: 4-Ethyl-piperazine-1-carbonyl chloride
The Article related to bactericides piperazinecarboxamidobenzylpenicillin, piperazinecarboxamidobenzylpenicillin, penicillin piperazinecarboxamidobenzyl, benzylpenicillin piperazinecarboxamido, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Name: 4-Ethyl-piperazine-1-carbonyl chloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics