Yang, Xi et al. published their research in Chinese Journal of Chemistry in 2022 | CAS: 70458-96-7

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents was written by Yang, Xi;Syed, Rasheed;Fang, Bo;Zhou, Cheng-He. And the article was included in Chinese Journal of Chemistry in 2022.Category: piperazines The following contents are mentioned in the article:

A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea, Et 4-chloroacetoacetate and various aldehydes. Some target mols. exhibited strong antibacterial activities, especially pyrimidinone benzimidazole hybrid 9e possessed the strongest inhibitory effects on the growth of E. faecalis and P. aeruginosa with a lower MIC value of 1 μg/mL than norfloxacin. Moreover, compound 9e displayed strong antibiofilm capacity, low drug resistance and excellent biosafety toward human red blood cells. Further research revealed that compound 9e could disrupt membrane integrity and cause leakage of cellular components such as proteins and nucleic acids. Meanwhile, compound 9e could decrease lactate dehydrogenase activity, block cell metabolism and interact with DNA in an intercalation manner. ADMET anal. predicated that mol. 9e possessed promising pharmacokinetic properties and good bioavailability profile. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics