With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
a) Preparation of Int. 67 The mixture of (3R)-3-(hydroxymethyl)- 1 -piperazinecarboxylic acid, 1 , 1 -dimethylethyl ester (2.41 g; 11.15 mmol), 3- nitro benzylbromide (2.53 g; 11.7mmol) and K2C03(1.34 g; 29 mmol) in ACN (50 ml) was stirred at r.t. for 12 h. The precipitate was filtered off. The filtrate was concentrated in vacuo. The crude was purified by column chromatography (eluent: PE/ EtOAc 4/1). The desired fractions were collected and the solvent was evaporated. Yield: 3.1 g of Int. 67 (88 % yield).
278788-66-2, 278788-66-2 (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820286, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; DIELS, Gaston, Stanislas, Marcella; SCHOENTJES, Bruno; VERSELE, Matthias, Luc, Aime; BERTHELOT, Didier, Jean-Claude; WILLEMS, Marc; VIELLEVOYE, Marcel; SOMMEN, Francois, Maria; WROBLOWSKI, Berthold; MEERPOEL, Lieven; WO2015/150557; (2015); A1;,
Piperazine – Wikipedia
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