Ruthenium catalyzed β-C(sp3)-H functionalization on the ‘privileged’ piperazine nucleus was written by Murugesh, V.;Bruneau, Christian;Achard, Mathieu;Sahoo, Apurba Ranjan;Sharma, Gangavaram V. M.;Suresh, Surisetti. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.HPLC of Formula: 21867-64-1 This article mentions the following:
β-C(sp3)-H functionalization on the ‘privileged’ piperazine nucleus was disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles I [R = Me, Et, n-Pr; R1 = H, 9-Cl, 7-CF3, etc.] from ortho-piperazinyl (hetero)aryl aldehydes was presented. This transformation was not limited to only ortho-piperazinyl aromatic aldehydes as N-heteroaryl piperazine like 8-methyl-2-(4-methyl-piperazin-1-yl)quinoline-3-carbaldehyde also served as a good substrate in this transformation to afford the corresponding piperazine fused aza-indole system in good yield. This transformation took place via the dehydrogenation of piperazine followed by an intramol. nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1HPLC of Formula: 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.HPLC of Formula: 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics