Antibacterial derivatives of 8-alkyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acids. II. 2-Piperazinyl and 2-(4-alkylpiperazinyl) derivatives was written by Pesson, M.;Antoine, M.;Chabassier, S.;Geiger, S.;Girard, P.;Richer, D.;De Lajudie, P.;Horvath, E.;Leriche, B.;Patte, S.. And the article was included in European Journal of Medicinal Chemistry in 1974.Name: 1-Propylpiperazine This article mentions the following:
Piperazinylpyridopyrimidines I (R = Me, Et, CH2CH2OMe, tetrahydropyranyloxyethyl, CH2CH2OH; R1 = Et; R2 = Me, Et, Pr, allyl, Bu, CH2CH2OH, CH2CH2OMe, CH2CN, CH2CO2Et) were prepared by aminating chloropyridopyrimidines II and were hydrolyzed to acids I (R1 = H). I (R2 = H) were similarly prepared via I (R2 = CHO). I (R1 = H) are bactericidal and their activity is discussed relative to R and R2. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Name: 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Name: 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics