Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1,3,5-triazine hybrids as anticancer agents was written by Kumar, Ravi;Gupta, Leena;Pal, Pooja;Khan, Shahnawaz;Singh, Neetu;Katiyar, Sanjay Babu;Meena, Sanjeev;Sarkar, Jayanta;Sinha, Sudhir;Kanaujiya, Jitendra Kumar;Lochab, Savita;Trivedi, Arun Kumar;Chauhan, Prem M. S.. And the article was included in European Journal of Medicinal Chemistry in 2010.Electric Literature of C7H16N2 This article mentions the following:
A series of tetrahydro-β-carbolines and 1,3,5-triazine hybrids have been synthesized and evaluated for their cytotoxicity against a panel of eight human cancer cell lines and normal human fibroblasts (NIH3T3). It led us to discovery of three racemic compounds which are selectively cytotoxic towards KB (oral cancer) cell line with IC50 values of 105.8, 664.7 and 122.2 nM, resp.; their enantiopure forms are less active and not selective. Enantiopure compound I (R = N-methylpiperazine) showed 2.5 times more selectivity towards MCF7 cells over normal fibroblast NIH3T3 cells with an IC50 value of 740 nM, also arrests cell cycle in G1 phase and induces apoptosis in MCF7 and MDA MB231cell lines. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Electric Literature of C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics