Synthesis, characterization, and biological activity of novel metronidazole-piperazine amides was written by Al-Qtaitat, Malath A.;Saadeh, Haythem A.;Al-Bakri, Amal G.;Kaur, Hargobinder;Goyal, Kapil;Sehgal, Rakesh;Mubarak, Mohammad S.. And the article was included in Monatshefte fuer Chemie in 2015.Safety of 1-Propylpiperazine This article mentions the following:
A new series of metronidazole derivatives containing piperazine rings were prepared via the reaction of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetyl chloride with selected substituted piperazines in the presence of a base. Structures of the new compounds were confirmed by NMR and MS spectral data and by elemental analyses. The antibacterial and anti-parasitic activities of these compounds were evaluated in vitro. Some of the newly synthesized compounds exhibited superior activity against Clostridium sporogenes bacteria compared to the standard drug metronidazole (I). On the other hand, other derivatives exhibited remarkable antigiardial activity and were found to be more active than metronidazole with IC50 ranging from 1.8 to 6.7 μg/dm3. 1-Ethyl-4-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]piperazine (II) also exhibited antigiardial activity with similar IC50 value (7.6 μg/cm3) as compared to the reference drug metronidazole (IC50 = 7.4 μg/cm3). Similarly, several of the new compounds exhibited significant antitrichomonal activity and found to be more active than metronidazole with IC50 ranging from 6.7 to 8.65 μg/cm3 as compared to the reference drug metronidazole (8.9 μg/cm3). In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Safety of 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics