Category: 109-01-3

Product Details of 109-01-3In 2022 ,《Design and Synthesis of New Thiophene/Thieno[2,3-d]pyrimidines along with Their Cytotoxic Biological Evaluation as Tyrosine Kinase Inhibitors in Addition to Their Apoptotic and Autophagic Induction》 was published in Molecules. The article was written by Elmongy, Elshaymaa I.; Attallah, Nashwah G. M.; Altwaijry, Najla; AlKahtani, Manal Mubarak; Henidi, Hanan Ali. The article contains the following contents:

This work describes the synthesis and anticancer activity against kinase enzymes of newly designed thiophene and thieno[2,3-d]pyrimidines I [R = 2-(2-chloroacetyl)hydrazino, (3-methyl-2,5-dioxo-pyrrol-1-yl)amino, 2-[2-[(5-tert-butylisoxazol-3-yl)amino]acetyl]hydrazino, etc.] and II [R1 = Cl, (5-tert-butylisoxazol-3-yl)amino, (3-tert-butylisoxazol-5-yl)amino] along with their potential to activate autophagic and apoptotic cell death in cancer cells. The designed compounds were scanned for their affinity for kinases. The results were promising with affinity ranges from 46.7% to 13.3%. Mol. docking studies were performed, and the compounds were then screened for their antiproliferative effects. Interestingly, compounds I [R = 2-(2-chloroacetyl)hydrazino, (3-methyl-2,5-dioxo-pyrrol-1-yl)amino] resulted in higher cytotoxic effects than the reference standard against MCF-7 and HepG-2. The compounds were evaluated for their induction of apoptosis and/or necrosis on HT-29 and HepG-2. Three compounds induced significant early apoptosis compared to untreated control HT-29 cells, and four derivatives were more significant compared to untreated HepG-2 cells. Further investigated the effect of four compounds on the autophagy process within HT-29, HepG-2, and MCF-7 cells with flow cytometry. Similar to the apoptosis results, I [R = 2-(2-chloroacetyl)hydrazino] showed the highest autophagic induction among all compounds The potential inhibitory activity of the synthesized compounds on kinases was assessed. Screened compounds showed inhibition activity ranging from 41.4% to 83.5%. Compounds recorded significant inhibition were further investigated for their specific FLT3 kinase inhibitory activity. Noticeably, I [R = 2-(2-chloroacetyl)hydrazino] exhibited the highest inhibitory activity against FLT3. In the experimental materials used by the author, we found 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Ouyang, Jia-Sheng; Liu, Siqi; Pan, Bendu; Zhang, Yaqi; Liang, Hao; Chen, Bin; He, Xiaobo; Chan, Wesley Ting Kwok; Chan, Albert S. C.; Sun, Tian-Yu; Wu, Yun-Dong; Qiu, Liqin published an article in 2021. The article was titled 《A Bulky and Electron-Rich N-Heterocyclic Carbene Palladium Complex (SIPr)Ph2Pd(cin)Cl: Highly Efficient and Versatile for Buchwald-Hartwig Amination of (Hetero)aryl Chlorides with (Hetero)aryl Amines at Room Temperature》, and you may find the article in ACS Catalysis.Name: 1-Methylpiperazine The information in the text is summarized as follows:

A bulky and electron-rich N-heterocyclic carbene palladium complex (SIPr)Ph2Pd(cin)Cl was synthesized and characterized. It was found to be highly efficient and versatile for the synthesis of substituted amines via coupling of different (hetero)aryl chlorides with various (hetero)aryl amines at room temperature, especially for the challenging amination of five- or six-membered ring heteroaryl chlorides with five- or six-membered ring heteroaryl amines. It was also successfully applied to the synthesis of various com. pharmaceuticals and candidate drugs or compounds with potential pharmacol. activities in high yields. All of these demonstrate its excellent catalytic efficacy in Buchwald-Hartwig amination and broad application prospects in relevant pharmaceutical preparations DFT calculations suggest that the steric-induced electronic interaction makes the ligand more electron-donating and the steric effect effectively regulates the rotation of iPr-Ph-iPr group in the catalyzed system due to the introduction of the di-Ph skeleton. Considering the electronic effect and steric effect together, the oxidative addition activation barriers by (SIPr)Ph2 and (SIPr) ligands are close to each other. The reductive elimination was the rate-determining step of (SIPr)Ph2Pd(cin)Cl-catalyzed system in the catalytic cycle, the appropriate steric hindrance of (SIPr)Ph2 ligand greatly reduces the energy barrier of this step. The perfect combination of electron-donating and steric hindrance ability of the ligand significantly improves the catalytic activity. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Name: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Name: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Ravutsov, Martin; Mitrev, Yavor; Shestakova, Pavletta; Lazarova, Hristina; Simeonov, Svilen; Popova, Margarita published an article in 2021. The article was titled 《CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites》, and you may find the article in Nanomaterials.Related Products of 109-01-3 The information in the text is summarized as follows:

The post-synthesis procedure for cyclic amine (morpholine and 1-methylpiperazine) modified mesoporous MCM-48 and SBA-15 silicas was developed. The procedure for preparation of the modified mesoporous materials does not affect the structural characteristics of the initial mesoporous silicas strongly. The initial and modified materials were characterized by XRD, N2 physisorption, thermal anal., and solid-state NMR. The CO2 adsorption of the obtained materials was tested under dynamic and equilibrium conditions. The NMR data revealed the formation of different CO2 adsorbed forms. The materials exhibited high CO2 absorption capacity lying above the benchmark value of 2 mmol/g and stretching out to the outstanding 4.4 mmol/g in the case of 1-methylpiperazin modified MCM-48. The materials are reusable, and their CO2 adsorption capacities are slightly lower in three adsorption/desorption cycles. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Related Products of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Related Products of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kumar, Ravi R.; Kumar, Vijay; Kaur, Dilpreet; Nandi, Nilay K.; Dwivedi, Ashish R.; Kumar, Vinod; Kumar, Bhupinder published an article in 2021. The article was titled 《Investigation of Indole-3-piperazinyl Derivatives as Potential Antidepressants: Design, Synthesis, In-Vitro, In-Vivo and In-Silico Analysis》, and you may find the article in ChemistrySelect.Application of 109-01-3 The information in the text is summarized as follows:

In the current study, authors have designed and synthesized various indole functionalized piperazinyl derivatives I (n = 1, 2 and 3; R = CH(C6H5)2, C6H5, CH3, CH2C6H5 and CH2CH3) and evaluated them for in vitro MAO-A inhibitory activity and in vivo antidepressant-like activity. Most of the compounds were found to possess potent MAO-A inhibitory activity with IC50 values in the sub-micromolar range along with significant selectivity over MAO-B. Compounds I (n = 1; R = CH(C6H5)2) and I (n = 3; R = C6H5) emerged as the most promising reversible MAO-A inhibitors with IC50 values of 0.11±0.03μM and 0.14±0.02μM and displayed selectivity of 193 folds and 178 folds over Monoamine oxidase-B (MAO-B), resp. In the series, I (n = 1; R = CH(C6H5)2) showed good intracellular ROS inhibitory activity along with neuroprotective properties. These compounds were found nontoxic against SH-SY5Y cells and explored antidepressant activities. In the in vivo Forced swimming test (FST) and Tail suspension test (TST) studies, I (n = 1; R = CH(C6H5)2) exhibited potential antidepressant-like behavior similar to standard drug fluoxetine while compound I (n = 3; R = C6H5) showed antidepressant-like activity only in the TST studies. The mol. docking and dynamics studies further supported the results obtained in the in vitro and in vivo studies. Thus, the indole functionalized piperazinyl derivatives were found to be promising ligands and can be developed as new antidepressant mols. In the experimental materials used by the author, we found 1-Methylpiperazine(cas: 109-01-3Application of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《Development of a multitasking fluorescent probe for differentiating G-Quadruplex structures》 were Hu, Ming-Hao; Chen, Xiao; Tan, Jia-Heng. And the article was published in Dyes and Pigments in 2019. HPLC of Formula: 109-01-3 The author mentioned the following in the article:

G-quadruplexes exhibit extensive structural polymorphism, which are highly related to their biol. functions. To date, multitasking probes that can simultaneously discriminate among parallel, antiparallel G-quadruplexes and single-/double-stranded nucleic acids have never been reported. The authors designed a probe IZNP-2 (I) based on the photoinduced electron transfer (PeT) mechanism. Conformation anal. firstly revealed that IZNP-2 was a smart probe, of which the fluorescence varied according to its mol. conformations. Then, fluorescence assays demonstrated that IZNP-2 could not only differentiate between parallel and antiparallel G-quadruplexes, but also discriminate antiparallel G-quadruplexes from single-/double-stranded nucleic acids. To understand this multitasking ability, the authors performed various experiments, including absorption titrations, lifetime experiments, Job plot assays and 2-Ap experiments, to study the binding modes, which suggested that IZNP-2 might exhibit “”Stretched””, “”Semi-stretched”” and “”Stacked”” conformations when targeting different nucleic acid topologies, alleviating the PeT to different extents and thus inducing differentiable fluorescence. Furthermore, the authors broadened the application of IZNP-2 in discriminating between multimeric and monomeric G-quadruplexes. To the best of the authors’ knowledge, such a study provides a first example of developing a multitasking fluorescent probe for differentiating different G-quadruplex structures by exploiting the PeT mechanism. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3HPLC of Formula: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..HPLC of Formula: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C5H12N2In 2022 ,《Silver(I)-Based Molecular Perovskite Energetic Compounds with Exceptional Thermal Stability and Energetic Performance》 was published in Inorganic Chemistry. The article was written by Shang, Yu; Chen, Shao-Li; Yu, Zhi-Hong; Huang, Rui-Kang; He, Chun-Ting; Ye, Zi-Ming; Zhang, Wei-Xiong; Chen, Xiao-Ming. The article contains the following contents:

In recent years, mol. perovskite energetic materials have attracted more attention because of their simple synthesis processes, high thermal stabilities, excellent performances, and great significance as a design platform for energetic materials. To explore the possibility of the application of mol. perovskite energetic materials in heat-resistant explosives, four silver(I)-based mol. perovskite energetic compounds, (H2A)[Ag(ClO4)3], where H2A = piperazine-1,4-diium (H2pz2+) for PAP-5, 1-methyl-piperazine-1,4-diium (H2mpz2+) for PAP-M5, homopiperazine-1,4-diium (H2hpz2+) for PAP-H5, and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (H2dabco2+) for DAP-5, were synthesized by a one-pot self-assembly strategy and structurally characterized. The single-crystal structures indicated that PAP-5, PAP-M5, and DAP-5 possess cubic perovskite structures while PAP-H5 possesses a hexagonal perovskite structure. Differential thermal analyses showed that their onset decomposition temperatures are >308.3 °C. For PAP-5 and DAP-5, they have not only exceptional calculated detonation parameters (D values of 8.961 and 8.534 km s-1 and P values of 42.4 and 37.9 GPa, resp.) but also the proper mech. sensitivity (impact sensitivities of ≤10 J for PAP-5 and 3 J for DAP-5 and friction sensitivities of ≤5N for both PAP-5 and DAP-5) and thus are of interest as potential heat-resistant primary explosive components. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Synthetic Route of C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Synthetic Route of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Rapid functionalization of multiple C-H bonds in unprotected alicyclic amines》 was published in Nature Chemistry in 2020. These research results belong to Chen, Weijie; Paul, Anirudra; Abboud, Khalil A.; Seidel, Daniel. Formula: C5H12N2 The article mentions the following:

The synthesis of valuable bioactive alicyclic amines containing variable substituents in multiple ring positions typically relies on multistep synthetic sequences that frequently require the introduction and subsequent removal of undesirable protecting groups. Although a vast number of studies have aimed to simplify access to such materials through the C-H bond functionalization of feedstock alicyclic amines, the simultaneous introduction of more than one substituent to unprotected amines has never been accomplished. Here the authors report an advance in C-H bond functionalization methodol. that enables the introduction of up to three substituents in a single operation. Lithiated amines are first exposed to a ketone oxidant, generating transient imines that are subsequently converted to endocyclic 1-azaallyl anions, which can be processed further to furnish β-substituted, α,β-disubstituted, or α,β,α’-trisubstituted amines. This study highlights the unique utility of in situ-generated endocyclic 1-azaallyl anions, elusive intermediates in synthetic chem. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Reference of 1-MethylpiperazineIn 2021 ,《Experimental review of PEI electrodeposition onto copper substrates for insulation of complex geometries》 appeared in RSC Advances. The author of the article were Zirignon, J.-C.; Capezza, A. J.; Xiao, X.; Andersson, R. L.; Forslund, M.; Diner, P.; Olsson, R. T.. The article conveys some information:

Polyetherimide (PEI) was used for coating copper substrates via electrophoretic deposition (EPD) for elec. insulation. Different substrate preparation and elec. field application techniques were compared, demonstrating that the use of a pulsed voltage of 20 V allowed for the best formation of insulating coatings in the 2-6μm thickness range. The results indicate that pulsed EPD is the best technique to effectively coat conductive substrates with superior surface finish coatings that could pass a dielec. withstand test at 10 kV mm-1, which is of importance within the EV automotive industry. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Reference of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Reference of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wambua, Victor; Hirschi, Jennifer S.; Vetticatt, Mathew J. published an article in 2021. The article was titled 《Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects》, and you may find the article in ACS Catalysis.Formula: C5H12N2 The information in the text is summarized as follows:

A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a “”designed”” reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene with primary and secondary amines is investigated under synthetically relevant catalytic conditions using traditional intermol. 13C NMR methodol. at natural abundance. Switching to 1,4-dibromobenzene, a sym. bromoarene as the designed reactant, the same exptl. 13C KIEs are determined using an intramol. KIE approach. This rapid methodol. for KIE determination requires substantially less material and time compared to traditional approaches. Details of the Buchwald-Hartwig amination mechanism are investigated under varying synthetic conditions, namely a variety of halides and bases. The enantioselectivity-determining step of the L-proline catalyzed aldol reaction is also evaluated using this approach. We expect this mechanistic methodol. to gain traction among synthetic chemists as a practical technique to rapidly obtain high-resolution information regarding the transition structure of synthetically relevant reactions under catalytic conditions. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides》 was written by Brandes, Benjamin; Koch, Lukas; Hoenke, Sophie; Deigner, Hans-Peter; Csuk, Rene. Quality Control of 1-MethylpiperazineThis research focused onursolic acid piperazinylamide preparation antitumor structure activity; oleanolic acid piperazinylamide preparation antitumor structure activity; Amides; Cytotoxicity; N-oxide; Oleanolic acid; Ursolic acid. The article conveys some information:

3-O-Acetyl-ursolic acid and 3-O-acetyl-oleanolic acid were converted into piperazinylamides holding a distal NH, NMe or a NMe2 group. These compounds as well as the corresponding N-methyl-N-oxides were accessed. Their cytotoxicity was assessed in SRB assays employing a panel of human tumor cell lines and non-malignant fibroblasts (NIH 3T3). As a result, compounds holding a quaternary distal N-substituent were less cytotoxic that those holding a NH-moiety. Hence, the presence of a distal cationic center seems not to be a sufficient criterion for obtaining triterpenoids of high cytotoxicity and selectivity. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics