Category: 109-01-3

The author of 《Anion exchange membranes with “”rigid-side-chain”” symmetric piperazinium structures for fuel cell exceeding 1.2 W cm-2 at 60°C》 were Gao, Li; Wang, Ying; Cui, Chunyu; Zheng, Wenji; Yan, Xiaoming; Zhang, Peng; Hu, Lei; Wu, Xuemei; Zhuang, Lin; He, Gaohong. And the article was published in Journal of Power Sources in 2019. Category: piperazines The author mentioned the following in the article:

Developing anion exchange membranes (AEMs) having high hydroxide conductivity, swelling resistance and excellent alk. stability is a challenge for fuel cells now. Herein, a universal and controllable approach of grafting rigid side chain is first proposed to construct connected ion transport nano-channels. A new route is also provided to prepare AEMs with stable sym. saturated heterocyclic ammonium. The rigid side chain is introduced onto poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) by the Friedel-Crafts acylation with 4-fluorobenzoyl chloride and subsequent reaction between Ph fluoride and secondary amine of 1-methylpiperazine. Then the terminal piperazinium is produced by the reaction between tertiary amine of 1-methylpiperazine and Me iodide. Rigid branches expand free volume to construct connected ion transport nano-channels, leading to excellent conductivity (108 mS cm-1 at 60°C) that is higher than those of other reported sym. heterocyclic ammonium functionalized AEMs (33-89 mS cm-1 at 60°C). Due to the high conductivity, the H2/O2 cell employing this membrane achieves one of the highest peak power densities (1210 mW cm-2 at 2600 mA cm-2) so far. In addition, the IEC of the membrane remains constant after testing in 1 M NaOH at 60°C over 500 h.1-Methylpiperazine(cas: 109-01-3Category: piperazines) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Optimization of phthalazin-based aryl/heteroarylhydrazones to design new promising antileishmanicidal agents: synthesis and biological evaluation of 3-aryl-6-piperazin-1,2,4-triazolo[3,4-a]phthalazines》 was written by Romero, Angel H.; Rodriguez, Noris; Ramirez, Oscar G.. Computed Properties of C5H12N2 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

1-Monosubstituted and 1,4-substituted phthalazins based on aryl/heteroarylhydrazinyl have demonstrated attractive antileishmanial profiles against amastigote forms of the Leishmania braziliensis parasite. Further optimization of the mentioned acyclic scaffold motivated us to design a series of 3-aryl-1,2,4-triazolo[3,4-a]phthalazines, cyclic versions of the phthalazins based on aryl/heteroarylhydrazinyl, which have not been evaluated against Leishmania parasites yet. In order to compare to phthalazine-based aryl/heteroarylhydrazones, five essential 3-aryl-6-piperazin-1,2,4-triazolo[3,4-a]phthalazines were efficiently prepared in excellent yields (73-83%) through a facile one-pot procedure from 4-chloro-1-phthalazinyl-arylhydrazones via C-H dehydrogenative cyclization using silver(I) salt. From in vitro antileismanial evaluation, compound 2d, a nitro derivative, was identified as the most promising agent with a good anti-amastigote response (IC50 = 9.37 μM) and low relative toxicity against peritoneal macrophages (LD50 = 123.93 μM). A moderate response was found against clin. amastigote isolates of L. braziliensis, although superior compared to the reference glucantime. A comparison with their phthalazin analogs based on aryl/heteroarylhydrazinyl gave evidence that the efficacy of each chem. system is determined by the nature of the functionalization next to the aryl moiety, which suggests that different mechanisms of action are involved for each chem. system. The cyclized form led to an enhancement of the antileismanial activity compared to the acyclic form, but the nitroderivatives seemed to be highly more toxic than the parent non-cyclized compounds From the three compared phthalazine groups, 4-chloro-1-phthalazine-(5-nitrofuryl)hydrazinil with a nanomolar antileishmanial response was identified as a promising lead for further optimization, whereas compound 2d emerges as a prominent hit platform to prepare a group of derivatives based on phthalazine-1,2,4-triazolo bearing 3-nitro-Ph at the 3-position. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Computed Properties of C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Computed Properties of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Zhang, Fei-Yi; Lan, Xiao-Bing; Xu, Chang; Yao, Hua-Gang; Li, Tian; Liu, Feng-Shou. Formula: C5H12N2. The article was titled 《Rigid hindered N-heterocyclic carbene palladium precatalysts: synthesis, characterization and catalytic amination》. The information in the text is summarized as follows:

To explore the high efficiency of the Buchwald-Hartwig amination with a wide substrate scope, easily prepared and air stable palladium precatalysts bearing rigid hindered N-heterocyclic carbenes (NHCs) were synthesized and characterized. A simple and efficient protocol for the amination of (hetero)aryl chlorides with amines is described, which revealed that sterically encumbered NHC ligands are crucial to promote the transformation. It is highlighted that the most challenging reactions could be performed between less reactive five-membered heteroaryl chlorides and heteroanilines. This methodol. provides a rapid and straightforward access to a wide range of arylated amines with excellent functional group tolerance. Remarkably, the powerful synthetic utility of palladium precatalysts was further extended to the synthesis of pharmaceuticals. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Microwave-Assisted Cu(I)-Catalyzed Synthesis of Unsymmetrical 1,4-Diamino-2-butynes via Cross-A3-Coupling/Decarboxylative A3-Coupling》 was written by Xu, Xianjun; Feng, Huangdi; Van der Eycken, Erik V.. Safety of 1-MethylpiperazineThis research focused onunsym diamino butyne preparation chemoselective microwave irradiation; amine formaldehyde propiolic acid decarboxylative cross coupling copper. The article conveys some information:

1,4-Diamino-2-butynes display both chem. and physiol. properties. Here a highly efficient synthesis avenue to generate unsym. 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Safety of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Safety of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 109-01-3In 2020 ,《Metal-Free Synthesis of Thermally Stable Fluorescent p-Terphenyls by Ring Transformation of 2H-Pyran-2-ones》 was published in ChemistrySelect. The article was written by Chandrasekar, Subashini; Singh, Fateh V.. The article contains the following contents:

A metal-free approach for the synthesis of p-terphenyls I (Y = piperidin-1-yl, N,N-dimethylamin-1-yl, 4-methylpiperidin-1-yl, etc.) and cyclic p-terphenyls II and III is described via carbanion induced ring transformation reaction of 6-biphenyl-2H-pyran-2-ones IV with malononitrile, cyclohexanone and 1,4-dioxaspiro[4.5]decan-8-one resp. Addnl., the base-mediated ring transformation reactions were working smoothly under mild reaction conditions and ring transformation products I, II and III were isolated in good to excellent yields. The synthetic approach provides the flexibility of introducing of both electron-withdrawing and -donating functionalities in p-terphenyl architecture. Moreover, the photo phys. properties of compounds I, II and III were analyzed using UV-visible and Fluorescence Spectroscopy. The p-Terphenyls I (Y = 4-phenylpiperazin-1-yl) showed cyan fluorescence in chloroform (λmax (em): 508 nm) and acetonitrile (λmax (em): 420 nm) while cyclic p-terphenyl II (Y = 4-phenylpiperazin-1-yl) showed blue fluorescence in chloroform and 1,4-dioxane (λmax (em): 470 nm). Similarly, compound III (Y = 4-phenylpiperazin-1-yl) showed blue fluorescence in chloroform (λmax (em): 468 nm) and 1,4-dioxane (λmax (em): 473 nm). Addnl., the thermal stability of synthesized cyclic p-terphenyls III (Y = 4-methylpiperidin-1-yl, N,N-dipropylamin-1-yl, piperidin-1-yl) were also studied using TG and DTA techniques. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3HPLC of Formula: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..HPLC of Formula: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《A novel water-soluble perylenetetracarboxylic diimide as a fluorescent pH probe: Chemosensing, biocompatibility and cell imaging》 were Georgiev, Nikolai I.; Said, Awad I.; Toshkova, Reneta A.; Tzoneva, Rumiana D.; Bojinov, Vladimir B.. And the article was published in Dyes and Pigments in 2019. Quality Control of 1-Methylpiperazine The author mentioned the following in the article:

Herein the authors pay attention to the design, synthesis and sensor activity of a novel biocompatible perylene-3,4,9,10-tetracarboxylic diimide (PDI) pH-probe in water. The synthesized compound shows selective fluorescence signaling properties as a function of pH (pKa value of 6.35±0.02) which makes the probe suitable for pH determination in the physiol. range. Thus prepared water soluble fluorescent system demonstrate low cytotoxicity to L929 cell lines from 330 μM to 1.3 μM and cell permeability in the lower concentration range. That findings show the high potential of the newly prepared PDI probe for monitoring of pH variations in bio-samples. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K+ channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones》 was written by Romero, Angel H.; Sojo, Felipe; Arvelo, Francisco; Calderon, Christian; Morales, Alvaro; Lopez, Simon E.. Recommanded Product: 1-MethylpiperazineThis research focused ontriazolophthalazine preparation anticancer mol docking potassium channel; 1,2,4-triazolo-phthalazine; Anticancer activity; CH oxidative cyclization; Molecular docking; Nitro-substitution; Potassium-channel. The article conveys some information:

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramol. dehydrogenative cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). The nitro-derivatives were significantly more active against cancer strains than against the rest of tested compounds Specifically, compound I was identified as the most promising anticancer agent with significant biol. responses and low relative toxicities on human dermis fibroblast. The cytotoxic effect of compound I was more significant on PC3, MCF-7 and SKBr3 cancer cells with low-micromolar IC50 value ranging from 0.11 to 0.59μM, superior to Adriamycin drug. Mechanistic exptl. and theor. studies demonstrated that compounds I act as a K+ channel inhibitor in cancer models. Further mol. docking studies suggest that the EGFR Tyrosine Kinase enzyme may be a potential target for the most active 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C5H12N2In 2020 ,《Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives》 was published in Bioorganic Chemistry. The article was written by Ammar, Yousry A.; Farag, Awatef A.; Ali, Abeer M.; Ragab, Ahmed; Askar, Ahmed A.; Elsisi, Doaa M.; Belal, Amany. The article contains the following contents:

Compound I [R = Cl] was prepared via reaction of o-phenylene diamine with oxalic acid followed by chlorosulfonation with excess chlorosulfonic acid. A series of new sulfonylquinoxaline derivatives I [R = 3-MeOC6H4, 1-piperidyl, 2-(cyanomethyl)benzimidazol-1-yl, etc.] were obtained upon reacting compound I [R = Cl] with different types of amines. Compound II [R1 = R2 = Cl] was reacted with different secondary amines yielded mono and di secondary aminoquinoxaline derivatives II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = Cl, morpholino, NHNH2, etc.] depending on the reactivity difference of the two chlorine atoms. Hydrazinolysis of compound II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = Cl] furnished hydrazino quinoxaline derivatives II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = NHNH2]. Addnl. triazolo and pyrazolyl quinoxaline derivatives III and IV [R3 = 5-OH-3-Me-pyrazol-1-yl, 2-[(2,5-diphenylpyrazol-3-yl)methylene]hydrazino] were obtained through the reaction of compound II [R1 = 1-piperidyl; R2 = NHNH2] with Ph isothiocyanate, formylpyrazole and Et acetoacetate. All the synthesized compounds were screened for their antibacterial and antifungal activities. Compounds II [R1 = 1-piperidyl, R2 = Cl; R1 = R2 = 4-methylpiperazin-1-yl; R1 = 1-piperidyl, R2 = 4-methylpiperazin-1-yl; R1 = 4-methylpiperazin-1-yl, R2 = 1-piperidyl; R1 = morpholino, R2 = 4-methylpiperazin-1-yl; R1 = morpholino, R2 = NHNH2] showed good to moderate antimicrobial activity against the tested Gram-pos., Gram-neg. bacteria and fungi with MIC values ranging from 2.44 to 180.14μM. Their MBC values were also evaluated using the same tested microorganisms. Moreover, screening against multi-drug resistant strains revealed the promiscuity of these new derivatives, especially compound II [R1 = 1-piperidyl, R2 = Cl] that showed comparable antibacterial activity (MIC 4.91-9.82μM) with Norfloxacin (MIC 2.44-9.80μM). Furthermore, these compounds were evaluated as DNA Gyrase inhibitors and the obtained results were in the range of 15.69-23.72μM. Mol. docking studies of the promising derivatives into DNA Gyrase binding site proved the usefulness of hybridizing quinoxaline scaffold with SO2 and morpholine moieties as a hopeful strategy in designing new DNA Gyrase binding mols. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Computed Properties of C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Computed Properties of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Multi-cationic aminopyrene-based labeling tags for oligosaccharide analysis by capillary electrophoresis-mass spectrometry》 was published in Analytica Chimica Acta in 2020. These research results belong to Krenkova, Jana; Liskova, Marcela; Cmelik, Richard; Vigh, Gyula; Foret, Frantisek. Name: 1-Methylpiperazine The article mentions the following:

In this work, new multicationic aminopyrene-based labeling tags were designed and synthesized for oligosaccharide anal. by capillary electrophoresis-mass spectrometry (CE-MS). The starting compound, 8-aminopyrene-1,3,6-trisulfonic acid trisodium salt, was modified in order to form a sulfonamide derivative having three tertiary amines in the label structure. The sulfonamide derivative was further methylated to generate three permanently charged quaternary ammonium moieties on the label. The synthesized labels were characterized by NMR, IR, UV/Vis, fluorescence spectroscopy and mass spectrometry. Furthermore, the labels were applied for maltooligosaccharide standards as well as N-linked glycans labeling via reductive amination and followed by CE-MS anal. The CE-MS anal. of maltooligosaccharides labeled by these newly synthesized labels provided the sub-micromolar limit of detection based on the extracted ion electropherogram signals. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Name: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Name: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《New phenolic Mannich bases with piperazines and their bioactivities》 were Gul, Halise Inci; Tugrak, Mehtap; Gul, Mustafa; Mazlumoglu, Sertac; Sakagami, Hiroshi; Gulcin, Ilhami; Supuran, Claudiu T.. And the article was published in Bioorganic Chemistry in 2019. Safety of 1-Methylpiperazine The author mentioned the following in the article:

New Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substituted piperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-ones I [R = Me, Ph, benzyl, etc.] were synthesized with the reaction of vanillin derived chalcone compound (2-(4-hydroxy-3-methoxybenzylidene)indan-1-one), paraformaldehyde and suitable amine in 1:1.2:1 mol ratios. Compounds I were evaluated in terms of cytotoxic/anticancer and CA inhibitory effects. According to the results obtained, the compounds I [R = Ph, 3-trifluoromethylphenyl] had the highest potency selectivity expression (PSE) values (60.6 and 19.2, resp.). On the other hand, the compounds I [R = benzyl] (Ki = 209.6 ± 70.2 pM) and [R = 3-methoxyphenyl] (Ki = 342.66 ± 63.72 pM) had the lowest Ki values in CA inhibition experiments towards hCA I and hCA II, resp. In conclusion, the compounds I [R = phenyl] (with cytotoxic/anticancer activity), I [R = benzyl] (with hCA I inhibiting activity) and I [R = 3-methoxyphenyl] (with hCA II inhibiting activity) can be leading compounds of the study for further designs and evaluations. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Safety of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Safety of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics