Category: 109384-27-2piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

[Referential Example 16] 1-Methylpiperazin-2-one trifluoroacetic acid salt 4-Methyl-3-oxopiperazine-1-carboxylic acid tert-butyl ester (0.308 g) obtained in step 2) of Referential Example 15 was dissolved in dichloromethane (6 mL). Trifluoroacetic acid (3 mL) was added to the resultant mixture at room temperature, followed by stirring for 1.5 hours. The reaction solvent was evaporated under reduced pressure, and the residue was dried, to thereby give the title compound (0.485 g, quantitative amount). 1H-NMR(400MHz,CDCl3-CD3OD(15:1))delta:2.98(3H,s), 3.39(2H,t-like,J=6.1Hz), 3.54(2H,t-like,J=6.1Hz), 3.72(2H,s). MS(EI) m/z:114(M+).

109384-27-2, The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 – Methyl-piperazin-2-one hydrochloride (0.844 mmol, 127 mg) in dichloromethane was put on a column of Si-Carbonate (Silicycle, 1 g) and eluation with dichloromethane gave the free base 1 -methyl-piperazin-2- one. To this compound in 2-propanol (1 ml) were subsequently added 4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexanone (0.649 mmol, 200 mg) and aluminium isopropoxide (1.469 mmol, 300 mg) and the mixture was stirred at 60 C for one hour. Sodium triacetoxyborohydride (1.298 mmol, 275 mg) was added and the mixture was stirred at 60 C overnight. Then the reaction mixture was diluted with dichloromethane and water, the dichloromethane layer isolated by a phase separation filter and concentrated in vacuo. The crude product was was purified by column chromatography (silica gel; gradient of dichloromethane to dichloromethane / methanol 92/8) to give 4-((trans)-4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexyl)-1 -methylpiperazin-2-one (50 mg)., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 1,4-dibromobenzene (470 mg, 2.0 mmol), 1 -methylpiperazin-2-one hydrochloride (150mg, 1.0 mmol, from J&W PharmLab), palladium acetate (6.7 mg, 0.030 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.035 g, 0.060 mmol), and cesium carbonate (0.98 g, 3.0 mmol) in toluene (5.0 mL) was evacuated and refilled with nitrogen three times and then the reaction was stirred at 105C. overnight. The mixture was diluted with ethyl acetate, washed with water, brine, then dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexane (0-60%) to afford the desired product (0.26 g, 49%). LCMS calculated for C11H14BrN2O (M+H)+:m/z=269.0. Found 269.0., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; Incyte Corporation; Lu, Liang; He, Chunhong; Yao, Wenqing; US2014/45814; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

109384-27-2, 6-Chloro-3-[(S)-1-(6-fluoro-1-methyl-1 H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine(Intermediate E, SO.Omg, 0.152 mmol), KF (26.4mg, 0.455 mmol) and 1-methylperazine-2- one hydrochloride (51.9mg, 0.455 mmol) were suspended in NMP (1 ml_). The RM was stirred at 180 0C for 5 h. The mixture was diluted with EtOAc and washed with NaHCO3 10% (2 x) and water (4 x). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography and afforded the title compound as a light brown foam (tR 3.66 min (conditions 5), (tR 12.22 min (conditions 2), MH+ = 408.2, 1H-NMR in DMSO-d6: 7.92 (s, 1 H); 7.83 (d, 1 H); 7.49 (m, 3H); 7.11 (d, 1 H); 4.78 (m, 1H); 4.00 (d, 1H); 3.95 (S1 3H); 3.86 (d, 1 H); 3.67 (m, 2H); 3.30 (m, 2H); 2.80 (s, 3H); 1.71 (d, 3H)).

109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; FURET, Pascal; McCARTHY, Clive; SCHOEPFER, Joseph; STUTZ, Stefan; WO2011/15652; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Example 71] 1-[5-(5-Methylpyridin-2-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carbonyl]-4-methyl-3-oxopiperazine Triethylamine (0.330 mL) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (179 mg) were added at room temperature to a solution of 5-(5-methyl-2-pyridyl)-1-(3-pyridyl)-1H-pyrazole-3-carboxylic acid (0.218 g) obtained from Referential Example 9, 1-methyl-2-piperazinone hydrochloride (176 mg) obtained from Referential Example 15, and 1-hydroxybenzotriazole (143 mg) in N,N-dimethylformamide (15 mL), and the mixture was stirred at room temperature for 15.5 hours. The reaction solvent was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogencarbonate. The aqueous layer was further extracted with ethyl acetate four times. The organic layers were combined, and the combined organic layer was dried over sodium sulfate anhydrate. After a filtration step, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel flash column chromatography (dichloromethane – methanol), to thereby give the title compound (231 mg, 78%) as a solid product. 1H-NMR(400MHz,CDCl3)delta:2.34(3H,s), 3.03(3H,s), 3.46-3.50(2H,m), 4.03-4.07(1H,m), 4.41-4.45(2H,m), 4.85(1H,brs), 7.16-7.20(1H,m), 7.34-7.40(2H,m), 7.52-7.56(1H,m), 7.68-7.83(1H,m), 8.30(1H,s), 8.47(1H,brs), 8.59(1H,brs). ESI-MS m/z:377(M+H)+. Elementary analysis: as C20H20N6O2 Calculated: C,63.82;H,5.36;N,22.33. Found: C,63.65;H,5.28;N,22.24.

109384-27-2, 109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics