Category: 113534-02-4

Sreenivasa, S. published the artcile(E)-tert-Butyl 4-(N’-hydroxycarbamimidoyl)piperazine-1-carboxylate, Name: tert-Butyl 4-cyanopiperazine-1-carboxylate, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(12), o3347, database is CAplus and MEDLINE.

In the title compound, C₁₀H₂₀N₄O₃, the piperazine ring adopts a chair conformation. The mol. adopts an E conformation across the C=N double bond, with the -OH group and the piperazine ring trans to one another. Further, the H atom of the hydroxy group is directed away from the NH₂ group. An intramol. N-H¡¤¡¤¡¤O contact occurs involving the NH₂ group and the oxime O atom. In the crystal, mols. are linked via strong N-H¡¤¡¤¡¤O and O-H¡¤¡¤¡¤N H bonds with alternating R₂²(6) and C(9) motifs into tetrameric units forming R₄⁴(28) motifs. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C12H14O2, Name: tert-Butyl 4-cyanopiperazine-1-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Kulkarni, B. published the artcileDesign, synthesis and molecular docking studies of some 1-(5-(2-fluoro-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)piperazine derivatives as potential anti-inflammatory agents, Category: piperazines, the publication is Molecular Diversity, database is CAplus and MEDLINE.

The facile synthesis of a series of piperazinyl-substituted 1,2,4-oxadiazoles I (R = 4-ClC₆H₄CH₂, PhSO₂, 2-pyrazinylcarbonyl, etc.) in good to excellent yields is reported. The anti-inflammatory potential of the newly synthesized compounds was evaluated by anti-denaturation assay using diclofenac sodium as the reference standard Some of the compounds exhibited profound activity profile when compared to the standard drug. The mol. docking and SAR studies were carried out at the later stage to gain more insights about the promising activity profile of the synthesized mols.

Molecular Diversity published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C10H17N3O2, Category: piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Sreenivasa, S. published the artcile(E)-tert-Butyl 4-(N’-hydroxycarbamimidoyl)piperazine-1-carboxylate, Name: tert-Butyl 4-cyanopiperazine-1-carboxylate, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(12), o3347, database is CAplus and MEDLINE.

In the title compound, C₁₀H₂₀N₄O₃, the piperazine ring adopts a chair conformation. The mol. adopts an E conformation across the C=N double bond, with the -OH group and the piperazine ring trans to one another. Further, the H atom of the hydroxy group is directed away from the NH₂ group. An intramol. N-H···O contact occurs involving the NH₂ group and the oxime O atom. In the crystal, mols. are linked via strong N-H···O and O-H···N H bonds with alternating R₂²(6) and C(9) motifs into tetrameric units forming R₄⁴(28) motifs. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C12H14O2, Name: tert-Butyl 4-cyanopiperazine-1-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics