Category: 115761-79-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of the product from the previous step (150 mg, 0.41 mmol) in CH2CI2 (5 mL) was added in portions Et3N (126 mg, 1.25 mmol), followed by the addition in portions of l-(2,4-difluorophenyl)piperazine (82 mg, 0.41 mmol, 1.00 equiv). The resulting solution was stirred for 16 h at rt, then quenched by the addition of 15 mL H20 and extracted with 2×30 mL of EtOAc. The combined organic layers were concentrated under vacuum to afford 170 mg (92%) of the title compound as an off-white solid. LC-MS: (ES, m/z) 448

115761-79-0, 115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

1- (2, 4-Difluoro-phenyl) -piperazine (3.3 mmol; prepared by reacting piperazine with 1-BROM-2, 4-difluorobenzene according to the procedure described in WO 01/92264) was dissolved in 20 mL of THF and 1.1 eq. OF PROPARGYL bromide was added, followed by [how much?] eq. of anhydrous K2CO3. The reaction mixture was stirred at room temperature for 18 hours. It was then diluted with EtOAc and washed with brine, dried with Na2SO4 and concentrated to afford 1-(2, 4-difluoro-phenyl) -4-prop-2- ynyl-piperazine., 115761-79-0

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BIOGEN IDEC MA INC.; WO2004/92171; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 2 2-[4-(2,4-Difluorophenyl)piperazin-1-yl]ethanol Formula IX: n=2, STR13 A solution of 72 g of 4-(2,4-difluorophenyl)piperazine and 50 g of 2-bromoethanol in 300 ml of xylene containing 55 ml of triethylamine is heated under reflux for 6 hours. The solution is then cooled and ether is added. The precipitate of triethylamine hydrobromide formed is filtered off and the filtrate is concentrated in vacuo. The residue obtained is then crystallized from an isopropyl ether/pentane mixture. The crystals are filtered off, washed with the same mixture and then dried. 60 g of 2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethanol are thus recovered in the form of crystals melting at 54 C., 115761-79-0

115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Centre D’Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale; US4886805; (1989); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 3 (4, 5) (0.10 mmol) in DMSO (10 ml) were added ZH (0.12 mmol) and K2CO3 (27.6 mg 0.20 mmol). After stirring at 80 C for 8 hours, the mixture was cooled to room temperature and poured into water, the precipitation was filtered and dried directly for next step. To a solution of above solid (0.10 mmol) in dry THF (10 ml) was added LiAlH4 (11.4 mg, 0.30 mmol) at 0 C. After stirring at room temperature for 4 h, the mixture was quenched with water and extracted by CH2Cl2 (10 ml). The extraction was dried over anhydrous MgSO4 and filtered. The filtration was concentrated for next step. To a solution of above crude solid (0.12 mmol) in dry CH2Cl2 (10 ml) were added compound 6 (7-11) (0.10 mmol), TEA (22.2mg, 0.22 mmol) and BopCl (30.4 mg, 0.12 mmol). After stirring at room temperature for 12 h, the mixture was washed with brine and dried over anhydrous MgSO4, filtered and concentrated. The residue was purified by silica gel column (CH2Cl2 : MeOH = 100 : 1) to yield compounds 1, 2, A, B, C., 115761-79-0

115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Hongjian; Lv, Kai; Li, Xiaoning; Wang, Bo; Wang, Apeng; Tao, Zeyu; Geng, Yunhe; Wang, Bin; Huang, Menghao; Liu, Mingliang; Guo, Huiyuan; Lu, Yu; Chinese Chemical Letters; vol. 30; 2; (2019); p. 413 – 416;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 30; 7-(2-(4-(2,4-Difluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-7H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, Method E; A. 4-Chloro-7-(2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; To a solution of the title A compound in Example 29, 7-(2-bromoethyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (225 mg, 0.817 mmol) and 1-(2,4-difluorophenyl)piperazine (193 mg, 0.976 mmol) in 1 mL of dry acetone is added potassium carbonate (322 mg, 2.44 mmol). The mixture is heated at 50 C. for 24 h, cooled to RT, concentrated in vacuo, and the residue taken up in water. The aqueous mixture is repeatedly extracted with EtOAc, and the combined organic extracts are dried (Na2SO4), filtered and evaporated to dryness. The residue is purified by column chromatography on silica gel, eluting with 2% MeOH in DCM to afford 4-chloro-7-(2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine as a yellow solid: 1H NMR (CDCl3) delta 2.68 (m, 4H), 2.77 (t, 2H, J=8.0 Hz), 3.01 (m, 4H), 4.19 (t, 2H, J=8.0 Hz), 4.88 (br s, 2H), 6.36 (d, 1H, J=4.0 Hz), 6.77-6.87 (m, 3H), 6.96 (d, 1H, J=4.0 Hz).

115761-79-0, 115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Moorman, Allan R.; US2008/242672; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3 (100 mg, 0.23 mmol) in acetonitrile (CH3CN, 30 mL) was added thecorresponding arylpiperazine (1.2 equiv.) and potassium carbonate (6.0 equiv.). The reaction mixturewas stirred at reflux for 16 h. After cooling to ambient temperature, the reaction mixture was filteredthrough a Buchner funnel. After filtration, the filtrate was concentrated in vacuo and the residue waspuried by silica gel column chromatography using ethyl acetate/petroleum ether (1/4,v/v) as eluentto afford the corresponding products (4-21).

115761-79-0, 115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Chen, Hong; Xu, Bing-Bing; Sun, Tao; Zhou, Zhan; Ya, Hui-Yuan; Yuan, Mu; Molecules; vol. 22; 11; (2017);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a flask chargedwith 50 mL of CH3CNwas added 2.5mmol of compound6 and appropriate piperazine derivatives (3a-w, 1.5 eq.) and thereaction mixturewas refluxed for 10-38 h until the complete consumptionof starting material as detected by TLC. After the completion of thereaction, the reaction mixture was treated with ice and the resultingsolid was filtered and washed with water (2 × 25 mL). The residuewas purified with a silica gel column chromatography and was elutedwith dichloromethane: methanol (40:1) to afford corresponding products7a-w in 49-82% of yields

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference：
Article; Patel, Rahul V.; Mistry, Bhupendra; Syed, Riyaz; Rathi, Anuj K.; Lee, Yoo-Jung; Sung, Jung-Suk; Shinf, Han-Seung; Keum, Young-Soo; European Journal of Pharmaceutical Sciences; vol. 88; (2016); p. 166 – 177;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-(4-bromobutyl)phthalimide (5 g, 17.73 mmol) and 1- (2,4-difluoro-phenyl)-piperazine (17.73 mmol) in 2-butanone (100 mL), potassium carbonate (26.6 mmol) and potassium iodide (13.3 mmol) were added. The resulting mixture was heated at 900C overnight. After cooling the solution was filtered and evaporated to dryness. The residue was dissolved in dichloromethane (100 mL) and washed with water. The organic phase was dried over sodium sulphate and evaporated. This material was dissolved in ethanol (100 mL) and hydrazine (2 eq) was added. The solution was refluxed for 4 hours when a thick precipitate formed. Cone. HCl (5 mL) was then added and the mixture heated for a further hour. After cooling the solvent was evaporated and the residue dissolved in 2M HCl (100 mL). This solution was filtered and the aqueous filtrate evaporated again to dryness. The resulting residue was taken in isopropanol (30 mL) and filtered to give the hydrochloride salt of the required product. The salt was converted in the free amine by dissolution in NaOH (15% w/w) and extraction with dichloromethane. (2.6 g, 54%). 1H-NMR (CDCl3) S 1.3 (br s, 2H), 1.46-1.58 (m, 4H), 2.41 (t, 2H), 2.62 (s, 4H), 2.73 (t, 2H), 3.05 (br s, 4H), 6.77-6.83 (m, 2H), 6.87-6.94 (m, IH) (M+l) e/z 270, 115761-79-0

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SIENA BIOTECH S.P.A.; WO2006/8133; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115761-79-0

General procedure: To a solution of methyl hydrazinecarbodithioate 1 (0.34 g, 3 mmol) in ethanol (5 mL) was added the appropriate 1-substituted piperazine 2a-m (6 mmol), and the reaction mixture was stirred at reflux until the evolution of methyl mercaptan almost ceased (it took 5-10 h, and methyl mercaptan was detected by the moistened Pb(OAc)2 paper placed at the upper end of the reflux condenser). After cooling to room temperature, the precipitate was collected by filtration, dried in air. The crude product was purified by recrystallization from the appropriate solvent to give compounds 3a-m.

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Lin, Hui-Hui; Wu, Wei-Yao; Cao, Sheng-Li; Liao, Ji; Ma, Li; Gao, Man; Li, Zhong-Feng; Xu, Xingzhi; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3304 – 3307;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115761-79-0

General procedure: To a solution of methyl hydrazinecarbodithioate 1 (0.34 g, 3 mmol) in ethanol (5 mL) was added the appropriate 1-substituted piperazine 2a-m (6 mmol), and the reaction mixture was stirred at reflux until the evolution of methyl mercaptan almost ceased (it took 5-10 h, and methyl mercaptan was detected by the moistened Pb(OAc)2 paper placed at the upper end of the reflux condenser). After cooling to room temperature, the precipitate was collected by filtration, dried in air. The crude product was purified by recrystallization from the appropriate solvent to give compounds 3a-m.

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Lin, Hui-Hui; Wu, Wei-Yao; Cao, Sheng-Li; Liao, Ji; Ma, Li; Gao, Man; Li, Zhong-Feng; Xu, Xingzhi; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3304 – 3307;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics