Category: 120737-59-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

(a) te?^-Butyl 4-(3-cyano-5-(ethoxycarbonyl>6-methylpyridin-2-yl)-3-methylpiperazine- 1-carboxylate; Ethyl 6-chloro-5-cyanonicotinate (0.500 g, 2.4 mmol), tert-butyl 3-methylpiperazine-1- carboxylate (0.480 g, 2.40 mmol), and DIPEA (0.41 mL, 2.40 mmol) were dissolved in DMF (4 mL) and heated at 100 ¡ãC for 8 h. The reaction mixture was cooled to room temperature and the solvent concentrated under reduced pressure. The material was partitioned between EtOAc (50 mL) and saturated aqueous NaHCO3 (2 x 30 mL). The organics were washed with EPO brine (30 mL), dried (Mg5O4) and concentrated under reduced pressure to afford the crude product. No purification was done., 120737-59-9

The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2006/73361; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution OF 3-METHYL-PIPERAZINE-L-CARBOXYLIC acid tert-butyl ester (1.0 g, 5.3 mmol) and OF L-BROMO-4-TRIFLUOROMETHYL-BENZENE (1.0 g, 4.4 mmol) in toluene (10 ml) were added sodium-tert butylate (0.6 g, 6.2 mmol), 2- (DICYCLOHEXYLPHOSPHINO) biphenyl (31 mg, 89 mmol), and tris (dibenzylideneacetone) dipalladium-chloroform complex (23 mg, 22 mmol). The reaction mixture was then stirred for 16 hours at 80 ¡ãC. After allowing to cool to room temperature the reaction mixture was concentrated IN VACUO and purified by column chromatography (Si02, 70g, heptane/ethyl acetate 0-30percent) to give the title compound as a light brown solid (0.47 g, 31 percent). MS (m/e): 345.2 (M+HT, 100percent).

120737-59-9, The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/23260; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE D rac-3-Methyl-4-(4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester To a solution of 3-Methyl-piperazine-1-carboxylic acid tert-butyl ester (1.0 g, 5.3 mmol) and of 1-Bromo-4-trifluoromethyl-benzene (1.0 g, 4.4 mmol) in toluene (10 ml) were added sodium-tert butylate (0.6 g, 6.2 mmol), 2-(dicyclohexylphosphino)biphenyl (31. mg,89 mmol), and tris(dibenzylideneacetone)dipalladium-chloroform complex (23 mg, 22 mmol). The reaction mixture was then stirred for 16 hours at 80¡ã C. After allowing to cool to room temperature the reaction mixture was concentrated in vacuo and purified by column chromatography (SiO2, 70 g, heptane/ethyl acetate 0-30percent) to give the title compound as a light brown solid (0.47 g); MS (m/e): 345.2 (M+H+, 100percent)., 120737-59-9

Big data shows that 120737-59-9 is playing an increasingly important role.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 135 1-fluoro-4-nitrobenzene (5.0 g, 35.46 mmol, 1.0 eq) and 248 tert-butyl 3-methylpiperazine-1-carboxylate (7.09 g, 35.46 mmol, 1.0 eq) in 95 DMSO (40 mL) was added 64 K2CO3 (9.78 g, 70.92 mmol, 2.0 eq). The reaction mixture was heated at 120¡ã C. for 16 h. Progress of the reaction was monitored by LCMS. Upon the consumption of starting material, mixture was diluted with water (100 mL) and extracted with ethyl acetate (200 mL¡Á2). Combined organic layer was washed with water (50 mL¡Á3), dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude residue was purified by flash chromatography using 19 ethyl acetate: 20 hexane as eluents to obtain 249 tert-butyl 3-methyl-4-(4-nitrophenyl)piperazine-1-carboxylate (5.5 g, 48.67percent). (0378) LCMS: 322 [M+1]+, 120737-59-9

The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Referential Example 83]; 3,4-Dimethylpiperazine-1-carboxylic acid tert-butyl ester ; [] 3-Methylpiperazine-1-carboxylic acid tert-butyl ester (5.70 g) obtained from Referential Example 82 was dissolved in methanol (100 mL). To the resultant solution, 10percent palladium-carbon (0.59 g), 35percent aqueous formalin (9.7 mL), and 1M HCl in ethanol (31.3 mL) were added at room temperature, followed by stirring in a hydrogen atmosphere for 15 hours. After the system was purged with nitrogen, insoluble matter was filtered off, and the solvent of the filtrate was evaporated under reduced pressure. To the residue, chloroform – methanol (9percent) was added, and the resultant mixture was alkalinized through addition of aqueous sodium hydroxide, followed by partition. The aqueous layer was extracted with chloroform – methanol (9percent). The organic layers were combined and washed with saturated brine, and then dried over sodium sulfate anhydrate, followed by filtration. The solvent was evaporated under reduced pressure, and the residue was purified through silica gel column chromatography (chloroform – methanol), to thereby give the title compound as an oily product (3.10 g, 51percent).1H-NMR(400MHz,CDCl3)delta: 1.04(3H,d,J=6.3Hz), 1.46(9H,s), 1.95-2.20(2H,m), 2.28(3H,s), 2.50-2.78(2H,br), 2.90-3.05(1H,br), 3.88(1H,br). MS(ESI)m/z: 215(M+H)+.

120737-59-9, Big data shows that 120737-59-9 is playing an increasingly important role.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1591443; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics