Category: 129779-30-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 5-fhioroquinoline-8-carbonitrile (compound lc, 1.4 g, 8.1 mmol) in DMSO (20 mL) was added (3/^,5.S’)-3,5-dimethylpiperazine- 1 -carboxylate (compound Id) (1.7 g, 1.7 mmol) and DIEA (878 mg, 6.8 mmol). The reaction mixture was stirred at 120 C for 3 hrs, then cooled to room temperature, diluted with water (100 mL), and extracted with EA (150 mL) twice. The combined organic layer was washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 80 g, 10% to 50% EtOAc in PE). The purified intermediate was dissolved in DCM (20 mL) and TFA (5 mL) was added. The reaction mixture was stirred at room temperature for 3 hrs, then concentrated to afford a crude compound 3b (1.6 g, 75% yield). MS: calc?d 266 [(M+H)+], measured 266 [(M+H)+], 129779-30-2

As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DEY, Fabian; QIU, Zongxing; ZHU, Wei; ZOU, Ge; (55 pag.)WO2020/20800; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

STEP B; Acetyl chloride (0.216 ml, 3.04 mmol) was added to a stirred solution of (3S.5R)- 3,5-dimethyl-piperazine-i-carboxylic acid tert-butyl ester (500 mg, 2.34 mmol) and TEA (0.49 ml, 3.51 mmol) in DCM (20 ml). The mixture was stirred at room temperature overnight, then the solvent was evaporated and the residue was partitioned between Et2O and 5% citric acid. The organic phase was dried over Na2SO4 and evaporated in vacuo to give 545 mg of (3S,5R)-4-acetyl-3,5-dimethyl- piperazine-1-carboxylic acid tert-butyl ester as a colourless oil. Y= 90%, 129779-30-2

The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Adding ZTH-1 (10.7g, 50mmol, 1eq) into 250ml flask; adding 100ml tetrahydrofuran, kalium carbonicum (10.35g,75mmol, 1.5eq) and methyl iodide (8.52g, 60mmol, 1.2eq) in turn; reacting under room temperature overnight; filteringand condensing, adding 100ml water and 100ml dichloromethane into the residue; and rinsing with dichloromethane(50ml x twice), merging organic layer, rinsing with saturated brine, drying with anhydrous sodium sulfate, condensing,and column chromatography of the residue (methanol : dichloromethane = 1:20), 5.7g orange-colored oily substance ZTH-2 is obtained, wherein the yield is 50%.

129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Maidixian Pharmaceutical Inc.; Zhang, Nan; Zhong, Rong; ZHANG, Nan; ZHONG, Rong; EP2589601; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,129779-30-2

To a stirred solution of compound 1(2.1 g, 1 eq.) and compound 2 (2.3 g, 1 eq.) in ACN (20 mL), potassium carbonate (4.1 g, 3 eq.) was added. The reaction mixture was stirred at room temperature for 16 h. The reaction completion was monitored by TLC. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water and brine, dried over anhydrous Na2504, filtered and concentrated under reduced pressure to give a crude residue which was purified by silica gel column chromatography to afford compound 3.

The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICALS INC.; LUEDTKE, Gregory; BHAGWAT, Shripad; (99 pag.)WO2018/119362; (2018); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

[4990] A solution of N-(4-(chloi methyl)phenyl)thiomotpholine-4-carboxamide 1,1-dioxide (l.OOOg.3.303 mmol), tert-butyl (3S,5R)-3.5-dimethylpipeiazine-l-carboxylate (1.416 g.6.606 mmol) and potassium carbonate (1.369 g, 9.909 mmol) in acetonitrile (50 mL) prepared at the room temperature was stirred at the same temperature for 18 hr and concentrated under the reduced pressure. Then, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgS0 , filtered, and concentrated in vacuo. The residue was diluted with diethylether (15 mL) and stirred. The resulting precipitates were collected by filtration, washed by diethylether, and dried to give tert-butyl (2S,6R)-4-(4-(l,l-dioxidothiomorpholine-4-carboxamido)benzyl)-2,6-dimethylpiperaz ine-l-carboxylate as pale yellow solid (1.580 g, 99.5 ).

129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; KIM, Yuntae; LEE, Chang Sik; SONG, Hyeseung; GWAK, Dal-Yong; LEE, Jaeyoung; OH, Jung Taek; LEE, Chang Gon; KIM, II Hyang; (1041 pag.)WO2017/23133; (2017); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

129779-30-2, To a solution of tert-butyl czs-3,5-dimethylpiperazine-l-carboxylate (1.80 g, 8.40 mmol) in DCM (20 mL) was added a 37% HCHO solution (0.34 mL, 12.0 mmol) dropwise at 0 C, followed by portion- wise addition of Na(OAc)3BH (2.31 g, 10.9 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with DCM (30 mL) and washed with NaHC03 (20 mL) solution. The organic layer was separated, washed with brine (20 mL), dried over anhydrous Na2S04 and concentrated in vacuo to afford tert-butyl czs-3,4,5- trimethylpiperazine-l-carboxylate (1.81 g crude) as a colorless liquid. This compound was used as such for the next reaction without further purification. LC/MS (ESI) m/e [M+H]+/RT (min)/%: 228.90/4.29/88.5%. 1H NMR (400 MHz, CDC13) delta 1.08 (d, J = 6.1 Hz, 6H), 1.48 (s, 9H), 2.04-2.18 (m, 2H), 2.26 (s, 3H), 2.56-2.62 (m, 2H), 3.78-3.98 (m, 2H).

129779-30-2 (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 10822535, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The (2i?,65)-l-(iV-benzyloxycarbonylglycyl)-2,6-dimethylpiperazine used as a starting material was prepared as follows :-; Diisopropylethylamine (0.4 ml) was added to a stirred mixture of ter t-butyl (3i?,55)-3,5-dimethylpiperazine-l-carboxylate (0.25 g; available from Atlantic SciTech Group, Inc., 601 East Linden Avenue, Linden, New Jersey 07036, USA)), N- benzyloxycarbonylglycine (0.296 g), 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (V) (0.555 g) and DMA (15 ml) and the resultant mixture was stirred at ambient temperature for 18 hours. The reaction mixture was evaporated and the residue was dissolved in a mixture of trifluoroacetic acid (1.5 ml) and methylene chloride (4.5 ml). The mixture was stirred at ambient temperature for 1 hour. The resultant mixture was evaporated. Methanol was added to the residue and the solution was loaded onto an Isolute SCX-2 cation exchange cartridge (20 g). The column was washed with methanol and the product was eluted using a 3M methanolic ammonia solution. There was thus obtained (2i?,6.S)-l-(N-benzyloxycarbonylglycyl)-2,6-dimethylpiperazine (0.46 g); Mass Spectrum: M+H+ 306; HPLC: method Bl, Retention Time 2.37 minutes.

129779-30-2, As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/32064; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

173 2-flH-Ihdazol-4-yl)-4-morpholin-4-yl-6-((2S.6R)-2A6-trimethyl-piperazin-l- ylmethylVthieno[3 ,2-dlpyrimidineTo (66) (1.5g) in ethanol (3OmL) was added sodium borohydride (Ig). After 4 h the reaction mixture was quenched with brine and the resulting solid was collected by filtration, and air dried to furnish 168 (2-chloro-4-morpholin-4-yl- thieno[3,2-d]pyrimidin-6-yl)-rnethanol (1.42g).To a solution of 168 (1.42g) in toluene (14ml), warmed to 400C, was added phosphorous tribromide (0.16ml). The resulting mixture was then heated to 1000C for 6 h, was cooled, diluted with chloroform, washed with brine, and dried (MgSO4). The solvent was removed in vacuo to yield 6-bromomethyl-2-chloro-4-morpholin-4- yl-thieno[3,2-d]pyrimidine, 169 (1.4Og). EPO A mixture of (3R,5S)-3,5-dimethyl-piperazine-l-carboxylic acid tert-buty ester (0.92g), 6-bromomethyl-2-chloro-4-mophiholin-4-yl-thieno[3,2-d]pyrimidine (Ig) and potassium carbonate (1.59g) in MeCN (10ml) was heated to reflux for 5 days. The reaction mixture was subsequently cooled, diluted with chloroform, washed with brine and dried (MgSO4), and the solvent was removed in vacuo. The residue was purified by flash column chromatography to yield (3S,5R)-4-(2-chloro- 4-mophiholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,5-dimethyl-piperazine-l- carboxylic acid tert-butyl ester, 170 (1.2g). Treatment of this compound with HCl in DCM/MeOH produced 2-chloro-6-(2S,6R)-2,6-dimethyl-piperazin- 1 -ylmethyl)-4- mophiholin-4-yl-thieno[3,2-d]pyrimidine, 171, which was then methylated using 37% formaldehyde solution and sodium borohydride in MeOH, furnishing 172. 1H NMR (400MHz, CDCl3) 1.17 (6H, d), 1.92 (2H, t), 2.3 (3H, s), 2.73 (2H, d), 2.83 (2H, m), 3.95 (4H, m), 4.03 (4H, m), 4.18 (2H, s), 7.36 (IH, s), 7.48 (IH, t), 7.56 (IH, d), 8.26 (IH, d), 9.00 (IH, s), 10.40 (IH, br m); MS (ESI+) 478 (MH+).

129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 2: To a suspension of 26 (2.00 g, 7.3 mmol) in toluene (28 ml) were added N-Boc cis-2,6-dimethylpiperazine (3.13 g, 14.6 mmol), Pd2(dba)3 (254 mg, 0.28 mmol), tri-tert-butylphosphonium tetrafluoroborate (212 mg, 0.73 mmol) and NaO-tert-Bu (1.05 g, 10.9 mmol). The mixture was refluxed under N2 overnight. After cooling to room temperature, the mixture was partitioned between EtOAc (150 mL) and water (100 mL). The insoluble was removed through filtration and washed with EtOAc. The EtOAc layer was separated and washed with brine, dried over anhydrous Na2SO4. After the removal of organic solvent in vacuo, the residue was purified through Biotage chromatography (EtOAc/hexane= 25/100 to 75/100 gradient) to give the desired product 27 (476 mg, 16%) as a faint yellow solid.

129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Jian-kang; Huang, Xiuli; Shamim, Khalida; Patel, Paresma R.; Lee, Arthur; Wang, Amy Q.; Nguyen, Kimloan; Tawa, Gregory; Cuny, Gregory D.; Yu, Paul B.; Zheng, Wei; Xu, Xin; Sanderson, Philip; Huang, Wenwei; Bioorganic and Medicinal Chemistry Letters; vol. 28; 20; (2018); p. 3356 – 3362;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics